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The chemokine superfamily
| Table 1. The chemokine superfamilya (tab001dab) | |||
| Chemokine family | Chemokines | Chemokine receptor | Expression profile of receptor |
| CC chemokines | MIP-1a, MCP-4, MCP-3, RANTES, MIP-5, MPIF-1, HCC-1 | CCR1 | M, act T, N, Ba, E, D |
| MCP-1, MCP-2, MCP-3, MCP-4, MCP-5 | CCR2 | M, act T, Ba, D, NK | |
| Eotaxin, Eotaxin-2, Eotaxin-3, MCP-2, MCP-3, MCP-4, RANTES, MIP-5 | CCR3 | act T, E, Ba, D | |
| TARC, MDC, RANTES, MIP-1a, MCP-1 | CCR4 | act T, Ba, D | |
| RANTES, MIP-1a, MIP-1b, MCP-2 | CCR5 | M, act T, D | |
| Exodus/LARC, MIP-3b | CCR6 | act T, B, imm D | |
| SLC/6Ckine, MIP-3b | CCR7 | T- and B-cell lines, D | |
| I-309, TARC, MIP-3b | CCR8 | act T, NK | |
| TECK, MCP-1, MCP-2, MCP-4, MIP-1b, MIP-1a, RANTES, Eotaxin | CCR9 | D, thy | |
| C-TACK, MCP-1 | CCR10 | Skin T cells | |
| MCP-1, ELC, SLC, TECK | CCR11 | Expressed in various organs | |
| CXC chemokines | IL-8, GCP-2 | CXCR1 | N, NK |
| IL-8, GCP-2, GRO-a/b/g, ENA-78, NAP-2, LIX | CXCR2 | N, NK | |
| IP-10, MIG, ITAC | CXCR3 | act T, NK | |
| SDF-1 | CXCR4 | T, M | |
| BLC | CXCR5 | B | |
| CXCL16 (SexCKine) | CXCR6 | Th1 effector cells, NK | |
| CX3C | Fracktalkine | CX3CR1 | M, act T, NK |
|
C chemokine |
Lymphotactin | XCR1 |
act T, NK |
| a Chemokines are divided into subfamilies that bind to different classes of receptor expressed on their target cells. Abbreviations: act T, activated T cell; B, B cell; Ba, basophil; D, dendritic cell; E, eosinophil; imm D, immature dendritic cell; M, monocyte; N, neutrophil; NK, natural killer cell; T, T cell; Th1, T helper 1 cell; thy, thymocyte; BLC, B lymphocyte chemokine; C-TACK, cutaneous T-cell-activating chemokine; ELC (Ebl-1), EBL-1-ligand chemokine; ENA-78, epithelial-cell-derived neutrophil-activating protein 78; GCP-2, granulocyte chemotactic protein 2; GRO, growth-related oncogene; I-309, (a nameless human chemokine); IL-8, interleukin 8; ITAC, interferon-inducible T-cell alpha chemoattractant; LIX, lipopolysaccharide-induced CXC chemokine; LARC, liver- and activation-regulated chemokine; MCP-1, monocyte chemoattractant protein 1; MDC, macrophage-derived chemokine; MIG, monokine induced by interferon g; MIP, macrophage inflammatory protein; MPIF-1, myeloid progenitor inhibitory factor 1; NAP-2, neutrophil-activating peptide 2; RANTES, ‘regulated on activation, normal T-cell expressed and secreted’; SDF-1, stromal-cell-derived factor 1; SLC, secondary lymphoid tissue chemokine; TARC, thymus- and activation-regulated chemokine; TECK, thymus-expressed chemokine. | |||
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