tab002dab: Hepatic expression of endothelial cell adhesion molecules

Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: (02)00419-2h.htm (shortcode: tab002dab); 12 February 2002
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Hepatic expression of endothelial cell adhesion molecules

Patricia F. Lalor and David H. Adams

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Table 2. Hepatic expression of endothelial cell adhesion molecules^a (tab002dab)
Endothelium	Condition	CD31	ICAM-1	VCAM-1	E-Sel	P-Sel	VAP-1	MAdCAM-1
Vascular endothelium	Normal	++	+	–	–	–	+++	–
Vascular endothelium	Inflamed	++	+++	++	+	+	+++	– or ++^b
Sinusoidal endothelium	Normal	+/–	+	–	–	–	++	–
Sinusoidal endothelium	Inflamed	+	++	+	–	–	+++	–
^a The liver contains distinct populations of endothelial cells that can be distinguished by their anatomical location and expression of adhesion molecules, both under normal conditions and in disease. ^b Depends on disease. Abbreviations: E-Sel, E-selectin; ICAM-1, intercellular adhesion molecule 1; MAdCAM-1, mucosal addressin cell adhesion molecule 1; P-Sel, P-selectin; VAP-1, vascular adhesion protein 1; VCAM-1, vascular cell adhesion molecule 1.

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