Patricia F. Lalor and David H. Adams

SDF, IL-8, RANTES, MCP-1, CXCL16

^a Differences in lymphocyte populations recruited to the different anatomical compartments can be attributed to differential expression of chemokines and adhesion molecules. Thus, CCR7-positive lymphocytes will be retained by biliary epithelial cells in response to SDF expression, whereas CXCR3-bearing lymphocytes will be recruited to sinusoidal endothelial cells expressing IP-10, MIG or ITAC. Under inflammatory conditions broader profiles of adhesion molecules and chemokines permit recruitment of a wider range of lymphocyte subsets. Note that cells are not recruited directly from the bile ductule, because bile ducts are not exposed to the blood stream; thus, the molecules listed under bile ductule are involved in retention.
Abbreviations: CXCL16, SexCkine or ligand for the BONZO receptor; E-Sel, E-selectin; ICAM, intercellular adhesion molecule; IL-8, interleukin 8; IP-10, interferon-g-inducible protein 10; ITAC, interferon-inducible T-cell alpha chemoattractant; MAdCAM-1, mucosal addressin cell adhesion molecule 1; MCP-1, monocyte chemoattractant protein 1; MIP, macrophage inflammatory protein; P-Sel, P-selectin; RANTES, ‘regulated on activation, normal T-cell expressed and secreted’; SDF, stromal-cell-derived factor; VAP-1, vascular adhesion protein 1; VCAM-1, vascular cell adhesion molecule 1.