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Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: (02)00448-9h.htm (shortcode: tab001ksb); 11 April 2002
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Mitochondrial diseases
Josephine S. Modica-Napolitano
and Keshav K. Singh
Author
contact details
| Table 1. Mitochondrial diseasesa (tab001ksb) | |
|
Tissue/organ affected |
Clinical condition |
|
Blood |
Pearson’s syndrome |
| Brain | Seizures Myoclonus Ataxia Stroke Demetia Migraine |
| Colon | Pseudo-obstruction |
| Eye | Optic neuropathy Ophthalmoplegia Retinopathy |
| Heart | Conduction disorder Wolff–Parkinson–White syndrome Cardiomyopathy |
|
Inner ear |
Sensorineural hearing loss |
| Kidney | Fanconi’s syndrome Glomerulopathy |
| Liver | Hepatopathy |
| Skeletal muscle | Myopathy Neuropathy |
| a Data in the table are derived from Ref. 38. Mitochondrial diseases can arise from mutations in nuclear DNA or in mitochondrial DNA. Deficits in ATP production might result from altered functions of proteins involved directly in oxidative phosphorylation or involved in communication between the nucleus and mitochondria, and might have deleterious effects on several organ systems. Many mitochondrial diseases are so new that they have not yet been mentioned in the medical textbooks or in the medical literature. | |
|
References cited in Table 1 38 White, A.J. (2001) Mitochondrial toxicity and HIV therapy. Sex Transm Infect 77, 158-173, PubMed |
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