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Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 9; 24 May 2005 Abstract
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The linked loci from the Framingham and Iceland genome-wide linkage studies for hand osteoarthritis prior to stratification by joint
John Loughlin
| Table 1. The linked loci from the Framingham and Iceland genome-wide linkage studies for hand osteoarthritis prior to stratification by joint | |||
| Study | Chromosomal loci | LOD | Radiographic characteristic |
| Framingham, USA (Ref. 10) | 1p31.1 | 2.96 | JSN |
| 2p23.2 | 2.23 | JSN | |
| 7p14.3 | 2.32 | JSN | |
| 9q21.2 | 2.29 | JSN | |
| 11q13.4 | 1.60 | JSN | |
| 12q24.33 | 1.66 | JSN | |
| 13q14.11-q14.3 | 1.61 | K/L | |
| Iceland (Ref. 12) | 19q12-q13.33 | 1.83 | JSN and K/L |
| 2p23.2 | 1.48 | – | |
| 3p13 | 1.79 | – | |
| 4q32.2 | 2.61 | – | |
| Abbreviations: JSN, joint-space narrowing; K/L, Kellgren and Lawrence grading scheme; LOD, logarithm of odds. | |||
| References cited
in Table 1
10 Demissie, S. et al. (2002) Genome scan for quantity of hand osteoarthritis: the Framingham Study. Arthritis Rheum 46, 946-952, PubMed 12 Stefansson, S.E. et al. (2003) Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3. Am J Hum Genet 72, 1448-1459, PubMed |
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