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Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 11; 14 June 2005 Abstract
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Nesprin isoform nomenclature
Derek T. Warren, Qiuping Zhang, Peter L. Weissberg and Catherine M. Shanahan
| Table 1. Nesprin isoform nomenclature | ||
| Name | Nesprin isoform | Proposed function |
| Caenorhabditis elegans | ||
| ANC-1 (Ref. 18) | Single giant orthologuea | Nuclear migration/positioning Mitochondrial positioning |
| Drosophila melanogaster | ||
| MSP300 (Ref. 36) | Single giant orthologuea | Muscle development and function |
| Mammals | ||
| Syne-1A (Ref. 16) | Nesprin-1a | NMJ development |
| Syne-1B (Refs 16, 51) | Partial nesprin-1b | Golgi structure and function |
| Myne-1 (Ref. 15) | Nesprin-1a | Lamin binding (muscle-specific) |
| CPG2 (Refs 25, 97) | N-terminal nesprin-1 isoforms | Light response (brain-specific) |
| ENAPTIN (Ref. 23) | Nesprin-1 giant | Linking actin cytoskeleton to NE |
| Syne-2 (Ref. 16) | Partial nesprin-2g | Unknown |
| NUANCE (Ref. 17) | Nesprin-2 giant | Linking actin cytoskeleton to NE |
| a
No other isoforms have been identified to date. Abbreviations: NE, nuclear envelope; NMJ, neuromuscular junction. |
||
| References cited
in Table 1
15 Mislow, J.M. et al. (2002) Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C. J Cell Sci 115, 61-70, PubMed 16 Apel, E.D. et al. (2000) Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J Biol Chem 275, 31986-31995, PubMed 17 Zhen, Y.Y. et al. (2002) NUANCE, a giant protein connecting the nucleus and actin cytoskeleton. J Cell Sci 115, 3207-3222, PubMed 18 Starr, D.A. and Han, M. (2002) Role of ANC-1 in tethering nuclei to the actin cytoskeleton. Science 298, 406-409, PubMed 23 Padmakumar, V.C. et al. (2004) Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton. Exp Cell Res 295, 330-339, PubMed 25 Cottrell, J.R. et al. (2004) CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Neuron 44, 677-690, PubMed 36 Volk, T. (1992) A new member of the spectrin superfamily may participate in the formation of embryonic muscle attachments in Drosophila. Development 116, 721-730, PubMed 51 Gough, L.L. et al. (2003) Golgi localization of Syne-1. Mol Biol Cell 14, 2410-2424, PubMed 97 Nedivi, E. et al. (1996) A set of genes expressed in response to light in the adult cerebral cortex and regulated during development. Proc Natl Acad Sci U S A 93, 2048-2053, PubMed |
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