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Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 11; 14 June 2005 Abstract
PDF
Subcellular localisations of nesprins
Derek T. Warren, Qiuping Zhang, Peter L. Weissberg and Catherine M. Shanahan
| Table 2. Subcellular localisations of nesprins | ||
| Protein | Tissue/cell | Localisation |
| Nesprin-1 | Fibroblasts, COS7 (Ref. 23) | NE, nucleus, nucleolus, stress fibres, focal adhesions |
| MDBK (Ref. 51) | Golgi, centrosome | |
| Mitotic HeLa and NRK (Ref. 62) | Centrioles, spindle, midbody | |
| VSMCs (Ref. 12) | NE, nucleus | |
| Mouse C2C12 (Ref. 12) | NE, nucleolus, heterochromatin | |
| Cardiac muscle (Refs 16, 22) | NE, Golgi, muscle sarcomere, intercalated disc | |
| Skeletal muscle (Refs 16, 22) | NE, Golgi, muscle sarcomere (Z-line, M-line), synaptic nuclei | |
| Nesprin-2 | Fibroblasts, COS7 (Ref. 17) | NE, nucleoplasm, nucleolus, plasma membrane, lamellipodia, filopodia, stress fibres |
| VSMCs (Ref. 14) | NE, nucleus, plasma membrane | |
| Mouse C2C12 (Ref. 14) | NE, mitochondria, heterochromatin, plasma membrane | |
| Skeletal muscle (Refs 14, 22) | NE, muscle sarcomere (Z-line, A/I junction), sacoplasmic reticulum, mitochondrial membrane | |
| Abbreviations: NE, nuclear envelope; VSMCs, vascular smooth muscle cells. Cell lines: COS7, MDBK and NRK are monkey, bovine and rat kidney cell lines, respectively, whereas C2C12 is a myoblast cell line. | ||
| References cited
in Table 2
12 Zhang, Q. et al. (2001) Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. J Cell Sci 114, 4485-4498, PubMed 14 Zhang, Q. et al. (2005) Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle. J Cell Sci 118, 673-687, PubMed 16 Apel, E.D. et al. (2000) Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J Biol Chem 275, 31986-31995, PubMed 17 Zhen, Y.Y. et al. (2002) NUANCE, a giant protein connecting the nucleus and actin cytoskeleton. J Cell Sci 115, 3207-3222, PubMed 22 Zhang, Q. et al. (2002) The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300. Genomics 80, 473-481, PubMed 23 Padmakumar, V.C. et al. (2004) Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton. Exp Cell Res 295, 330-339, PubMed 51 Gough, L.L. et al. (2003) Golgi localization of Syne-1. Mol Biol Cell 14, 2410-2424, PubMed 62 Fan, J. and Beck, K.A. (2004) A role for the spectrin superfamily member Syne-1 and kinesin II in cytokinesis. J Cell Sci 117, 619-629, PubMed |
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