Stokoe_tab1: Different classes of phosphoinositide 3-kinase catalytic and regulatory subunits, and the phospholipid substrates they phosphorylate

Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 10; 7 June 2005 Abstract
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Different classes of phosphoinositide 3-kinase catalytic and regulatory subunits, and the phospholipid substrates they phosphorylate

David Stokoe

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Table 1. Different classes of phosphoinositide 3-kinase catalytic and regulatory subunits, and the phospholipid substrates they phosphorylate
	Enzyme	Regulatory subunit	Substrate^a
Class Ia	p110a, p110b, p110d	p85a, p85b, p55g	PtdIns = PtdIns(4)P = PtdIns(4,5)P₂
Class Ib	p110g	p101	PtdIns = PtdIns(4)P = PtdIns(4,5)P₂
Class II	PI3K-C2a, PI3K-C2b, PI3K-C2g	None	PtdIns > PtdIns(4)P >> PtdIns(4,5)P₂
Class III	Vps34p	p150	PtdIns
^a The relative affinities of the enzymes for different phosphoinositide substrates are indicated. Abbreviations: PI3K, phosphoinositide 3-kinase; PtdIns, phosphatidylinositol; PtdIns(4)P, phosphatidylinositol 4-phosphate; PtdIns(4,5)P₂, phosphatidylinositol (4,5)-bisphosphate; Vps, ‘vacuolar protein sorting’.

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