Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
DOI: 10.1017/S1462399405009488; 24 August 2005
Citation details: Sandra M. Sacre, Evangelos Andreakos, Peter Taylor, Marc Feldmann and Brian M. Foxwell (2005) Molecular therapeutic targets in rheumatoid arthritis.
Expert Rev. Mol. Med. Vol. 7, Issue 16, DOI: 10.1017/S1462399405009488

Molecular therapeutic targets in rheumatoid arthritis

Sandra M. Sacre, Evangelos Andreakos, Peter Taylor, Marc Feldmann and Brian M. Foxwell

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In an attempt to combat the pain and damage generated by rheumatoid arthritis (RA), new drugs are being developed to target molecular aspects of the disease process. Recently, a major development has been the use of biologicals (antibodies and soluble receptors) that neutralise the activity of tumour necrosis factor a (TNF-a) and interleukin 1 (IL-1), both of which are involved in disease progression. An increase in our understanding of cell and molecular biology has resulted in the identification and investigation of potential new targets, and also the refinement and improvement of current therapeutic modalities. This review describes therapies that are approved, in clinical trials or under pre-clinical investigation at the laboratory level, particularly focusing on cytokines, although other therapeutic targets of interest are mentioned.

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Figure 1. Mechanism of action of biological inhibitors.
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Figure 2. Extracellular molecular targets in rheumatoid arthritis (RA).
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Figure 3. Intracellular molecular targets in rheumatoid arthritis (RA).
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Table 1. Summary of rheumatoid arthritis therapeutics in development.
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