Butler_tab1: Clinical characteristics of Prader

Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 14; 25 July 2005 Abstract
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Clinical characteristics of Prader–Willi syndrome

Douglas C. Bittel and Merlin G. Butler

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Table 1. Clinical characteristics of Prader–Willi syndrome^a
Stage 1		Stage 2
Pregnancy and delivery	Neonatal period and infancy	Childhood	Adolescence and adulthood
Reduced fetal activity Breech delivery Pre-term or post-term delivery	Narrow forehead Undescended testicles Small genitals and testicles Poor muscle tone (hypotonia) Feeding problems Poor suck Sticky saliva Weak cry Temperature instability Developmental delay	Short stature Small hands and feet Light skin and eye colour Almond-shaped eyes Strabismus Myopia Skin picking Dental caries Excessive appetite/food foraging Obesity Intellectual disability Behavioural problems Temper tantrums Stubbornness Obsessive–compulsive behaviour	Short stature Small hands and feet Scoliosis Osteoporosis Delayed puberty Diabetes mellitus Depression Excessive sleepiness
^a For further information on clinical features seen in Prader–Willi syndrome, see Refs 2 and 134.

References cited in Table 1

2 Butler, M.G. and Thompson, T. (2000) Prader-Willi syndrome: clinical and genetic findings. The Endocrinol 10, 35-165

134 Butler, M.G., Lee, P.D.K. and Whitman, B.Y., eds (2005) Management of Prader-Willi Syndrome (3rd edn), Springer-Verlag, New York, NY, USA

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