Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
DOI: 10.1017/S1462399405009592; 30 August 2005
Citation details: Gisela Keller, Heinz Höfler and Karl-Friedrich Becker (2005) Molecular medicine of gastric adenocarcinomas.
Expert Rev. Mol. Med. Vol. 7, Issue 17, DOI: 10.1017/S1462399405009592

Molecular medicine of gastric adenocarcinomas

Gisela Keller, Heinz Höfler and Karl-Friedrich Becker

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Upper gastrointestinal (GI) tract malignancies, including carcinomas of the esophagus, the GI junction and the stomach, are among the most common cancers worldwide. Overall survival is poor because many patients present with locally advanced and often incurable disease. This review focuses on the pathogenesis of adenocarcinomas of the stomach. It summarises recent findings on genetic predisposition to gastric cancer, in particular in relation to germline mutations in the E-cadherin gene. It also describes the molecular basis of sporadic gastric cancer, including alterations in oncogenes, tumour suppressor genes and growth factors, and discusses how these findings might be used in the clinic for improved diagnosis and therapy.

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Figure 1. Genetic alterations in gastric cancer.
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Table 1. Overview of gastric cancer in hereditary tumour syndromes.
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