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Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 13; 18 July 2005 Abstract
PDF
Factors proposed to regulate endocytic pathways in Entamoeba histolytica
Richard C. Laughlin and Lesly A. Temesvari
| Table 1. Factors proposed to regulate endocytic pathways in Entamoeba histolyticaa | ||
| Factor | Pinocytosisb | Phagocytosisc |
| EhRabB | ? | + |
| EhRab5 | - | + |
| EhRab7 family | + | + |
| EhRacA | - | + |
|
EhPAK |
? | + |
| Actin | + | + |
| Myosin 1B | - | + |
| Phosphatidylinositol-3 kinase | + | + |
| Protein kinase C | ? | + |
| Lipid rafts | + | ? |
| Amoebapore A | ? | + |
| Cysteine protease (CPs) 1, 2, 112 | ? | + |
| L220 | ? | + |
| Hgl, Lgl, Igl subunits of the Gal/GalNAc-inhibitible lectin | ? | + |
| a
E. histolytica
acquires nutrients through endocytosis of cell debris, fluid phase particles,
erythrocytes, bacteria and whole cells. The ability to endocytose has been
correlated with the virulence of the organism. The endocytic process can
be divided into two distinct pathways: pinocytosis and phagocytosis. Factors
that influence these pathways either positively (+) or negatively (-) are
shown. The precise effects of some factors are not fully known (?). b Pinocytosis is a constitutive event that involves the uptake of small macromolecules or fluid-phase particles. Pinocytic vesicles become increasingly acidic as they mature. c Phagocytosis is the regulated uptake of large particles and whole cells, such as erythrocytes. |
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