|
|
|
|
|
|
|
|
|
|
Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 15; 10 August 2005 Abstract
PDF
Viral proteins essential for replication of varicella–zoster virus in human T cells and/or human skin
Mark Quinlivan and Judith Breuer
| Table 2. Viral proteins essential for replication of varicella–zoster virus in human T cells and/or human skina | |||||
| Open reading frame | Replication in T cells | Replication in skin | Refs | ||
| In vitro | In vivo | In vitro | In vivo | ||
| 1 | No | – | – | – | 108 |
| 4 | – | – | Yes | – | 187 |
| 5 (gK) | – | – | Yes | – | 183 |
| 10 | – | – | No | – | 188 |
| 13 | No | – | – | – | 108 |
|
14 (gC) |
– | – | No | Yes | 107 |
| 32 | No | – | – | – | 17, 189, 190, 191 |
| 47 | Yes | Yes | – | Yes | 17, 189, 190, 191 |
| 57 | No | – | – | – | 17, 189, 190, 191 |
| 62/71b | – | – | Yes | Yes | 192 |
| 63 | No | – | – | – | 193 |
| 63/70b | – | – | Yes | Yes | 193 |
| 64 | No | – | – | – | 193 |
| 64/69c | No | – | – | – | 193 |
| 65 | – | – | – | No | 194 |
| 66 | No | No | – | – | 189 |
| 67 (gI) | No | Yes | No | Yes | 23, 174, 178, 195 |
| 68 (gE) | – | No | Yes | No | 174, 196 |
| a‘Yes’
indicates the gene is essential for replication; ‘No’ indicates
the gene is not essential for replication; a dash indicates the requirement
has not been investigated. b At least one copy of diploid gene required. c Neither copy of diploid gene required. |
|||||
| References cited
in Table 2
17 Arvin, A.M. (1996) Varicella-zoster virus. In Virology (Fields, B.N. et al., eds), pp. 2547-2586, Lippincott-Raven Publishers, Philadelphia, PA, USA 23 Cohen, J.I. and Nguyen, H. (1997) Varicella-zoster virus glycoprotein I is essential for growth of virus in Vero cells. J Virol 71, 6913-6920, PubMed 107 Moffat, J.F. et al. (1998) Attenuation of the vaccine Oka strain of varicella-zoster virus and role of glycoprotein C in alphaherpesvirus virulence demonstrated in the SCID-hu mouse. J Virol 72, 965-974, PubMed 108 Soong, W. et al. (2000) Infection of human T lymphocytes with varicella-zoster virus: an analysis with viral mutants and clinical isolates. J Virol 74, 1864-1870, PubMed 174 Mo, C. et al. (2002) The requirement of varicella zoster virus glycoprotein E (gE) for viral replication and effects of glycoprotein I on gE in melanoma cells. Virology 304, 176-186, PubMed 178 Moffat, J. et al. (2002) Glycoprotein I of varicella-zoster virus is required for viral replication in skin and T cells. J Virol 76, 8468-8471, PubMed 183 Mo, C. et al. (1999) Characterization of Varicella-Zoster virus glycoprotein K (open reading frame 5) and its role in virus growth. J Virol 73, 4197-4207, PubMed 187 Sato, B. et al. (2003) Requirement of varicella-zoster virus immediate-early 4 protein for viral replication. J Virol 77, 12369-12372, PubMed 188 Cohen, J.I. and Seidel, K. (1994) Varicella-zoster virus (VZV) open reading frame 10 protein, the homolog of the essential herpes simplex virus protein VP16, is dispensable for VZV replication in vitro. J Virol 68, 7850-7858, PubMed 189 Moffat, J.F. et al. (1998) The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse. Proc Natl Acad Sci U S A 95, 11969-11974, PubMed 190 Besser, J. et al. (2003) Differentiation of varicella-zoster virus ORF47 protein kinase and IE62 protein binding domains and their contributions to replication in human skin xenografts in the SCID-hu mouse. J Virol 77, 5964-5974, PubMed 191 Besser, J. et al. (2004) Differential requirement for cell fusion and virion formation in the pathogenesis of varicella-zoster virus infection in skin and T cells. J Virol 78, 13293-13305, PubMed 192 Sato, B. et al. (2003) Mutational analysis of open reading frames 62 and 71, encoding the varicella-zoster virus immediate-early transactivating protein, IE62, and effects on replication in vitro and in skin xenografts in the SCID-hu mouse in vivo. J Virol 77, 5607-5620, PubMed 193 Sommer, M.H. et al. (2001) Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus. J Virol 75, 8224-8239, PubMed 194 Niizuma, T. et al. (2003) Construction of varicella-zoster virus recombinants from parent Oka cosmids and demonstration that ORF65 protein is dispensable for infection of human skin and T cells in the SCID-hu mouse model. J Virol 77, 6062-6065, PubMed 195 Ito, H. et al. (2003) Promoter sequences of varicella-zoster virus glycoprotein I targeted by cellular transactivating factors Sp1 and USF determine virulence in skin and T cells in SCIDhu mice in vivo. J Virol 77, 489-498, PubMed 196 Moffat, J. et al. (2004) Functions of the C-terminal domain of varicella-zoster virus glycoprotein E in viral replication in vitro and skin and T-cell tropism in vivo. J Virol 78, 12406-12415, PubMed |
|
home | search
| glossary
| links
| sitemap | contact
|
Expert Reviews in
Molecular Medicine © Cambridge University
Press ISSN 1462-3994 (Disclaimer
and copyright)
Editorial Office: Centre for Applied Research
in Educational Technologies (CARET), 1st Floor, 16 Mill Lane, Cambridge,
CB2 1SB, UK. Tel: +44 (0)1223 765 375; Fax: +44(0)1223 765 505; E-mail: ermm@caret.cam.ac.uk