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Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 15; 10 August 2005 Abstract
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Genes of varicella–zoster virus to which a function has been assigned

Mark Quinlivan and Judith Breuer

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Table 3. Genes of varicella–zoster virus to which a function has been assigned
Gene Function Protein characteristics HSV-1 homologue
1 Membrane protein non-VA No homologue
4 Transcriptional activator IE, VA, T UL 54
5 Glycoprotein K (gK) L, VA UL53
6 DNA helicase/primase component E, non-VA UL52
8 Deoxyuridine triphosphatase (dUTPase) E, non-VA UL50

9A

Stearoylated membrane protein (syncytia formation) L, non-VA UL49.5
10 Transcriptional activator IE, VA, T UL48
13 Thymidylate synthetase non-VA No homologue
14 Glycoprotein C (gC) L, VA UL44
16 Associated with DNA polymerase E, non-VA UL42
17 Host shut-off IE, VA, T UL41
18 Ribonucleotide reductase small subunit E, non-VA UL40
19 Ribonucleotide reductase large subunit E, non-VA UL39
28 DNA polymerase E, non-VA UL30
29 Single-stranded-DNA-binding protein E, non-VA UL29
31 Glycoprotein B (gB) L, VA UL27
33 Protease L, non-VA UL26
33.5 Assembly protein L, non-VA UL26.5
36 Pyrimidine deoxyribonucleotide kinase E, non-VA UL23
37 Glycoprotein H (gH) L, VA UL22
40 Major nucleocapsid antigen L, VA UL19
47 Protein kinase E, VA, T UL13
48 Deoxyribonuclease E, non-VA UL12

49

 Myristoylated protein L, non-VA UL11
50 Glycoprotein M (gM) L, VA UL10
51 Origin of replication (Ori)-binding protein E, non-VA UL9
52 Component of DNA helicase/primase E, non-VA UL8
55 Component of DNA helicase/primase E, non-VA UL5
59 Uracil-DNA glycosylase E, non-VA UL2
60 Glycoprotein L (gL) L, VA UL1
61 Transcriptional activator/repressor IE, VA ICP0
62, 71 Transcriptional activator IE, VA, T ICP4
63, 70 Transcriptional activator IE, VA, T US1
66 Protein kinase E, non-VA US3
67 Glycoprotein I (gI) L, VA US7
68 Glycoprotein E (gE) L, VA US8
Abbreviations: E, early protein; IE, immediate-early protein; L, late protein; T, tegument component; VA, virion-associated (physical component of virion); non-VA, non-virion-associated (not present in virion).

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