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Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 23; 18 October 2005 Abstract
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HLA class II haplotype associations with autoimmune disease
Oliver Brand, Stephen Gough and Joanne Heward
| Table 1. HLA class II haplotype associations with autoimmune disease | ||
| Disease | Predisposing haplotypes/allelesa | Protective haplotypes/alleles |
| Type 1 diabetes | DR3, DR4 | DR2 |
| Multiple sclerosis | DR2 | DRB1*01, *07, *11 |
| Rheumatoid arthritis | DRB1* 0401,*0404, *0405, *0408, *0102, *0101, *1402, *09, *1001 | DRB1*07, *1201, *1301, *0103, *1501 |
| Graves’ disease | DR3 | DR7 |
| Autoimmune Addison’s disease | DR3 | |
| Autoimmune hypothyroidism | DR3, DR4 | |
| Systemic lupus erythematosus | DR3, DR2, DR8 | |
| a
DR2 = DRB1*1501-DQB1*0602-DQA1*0102 DR3 = DRB1*03-DQB1*02-DQA1*05 DR4 = DRB1*04-DQB1*0302-DQA1*0301 DR7 = DRB1*07-DQB1*02/03032-DQA1*02 DR8 = DRB1*08-DQB1*04-DQA1*04 |
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