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Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 25; 8 November 2005 Abstract
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Some proposed target genes of PITX2

Tord A. Hjalt and Elena V. Semina

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Table 2. Some proposed target genes of PITX2
Gene Full name Cell type/organ Refs
PRL Prolactin Pituitary 66
HESX1 Homeobox gene expressed in ESCs Pituitary 73, 91
PROP1 Prophet of PIT1 Pituitary 73, 91
PLOD1 Pro-collagen lysyl hydroxylase Eye 121
TRIO Triple functional domain HeLa cells 122
DLX2 Distal-less homeobox 2 Tooth 81
CYCD2 Cyclin D2 Pituitary, heart 119
ANF/NPPA Atrial natriuretic factor Heart 75
FGF8 Fibroblast growth factor 8 Tooth 94
BMP4 Bone morphogenetic protein 4 Tooth 94
LHX3 Lim-domain homeobox gene 3 Pituitary 123
Abbreviations: ESC, embryonic stem cell; PIT1, pituitary-specific transcription factor 1.

References cited in Table 2

66 Szeto, D.P. et al. (1999) Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev 13, 484-494, PubMed

73 Gage, P.J., Suh, H. and Camper, S.A. (1999) Dosage requirement of Pitx2 for development of multiple organs. Development 126, 4643-4651, PubMed

75 Ganga, M. et al. (2003) PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5. J Biol Chem 278, 22437-22445, PubMed

81 Espinoza, H.M. et al. (2002) A molecular basis for differential developmental anomalies in Axenfeld-Rieger syndrome. Hum Mol Genet 11, 743-753, PubMed

91 Lin, C.R. et al. (1999) Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature 401, 279-282, PubMed

94 Liu, W. et al. (2003) Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development 130, 6375-6385, PubMed

119 Kioussi, C. et al. (2002) Identification of a Wnt/Dvl/beta-Catenin —> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 111, 673-685, PubMed

121 Hjalt, T.A., Amendt, B.A. and Murray, J.C. (2001) PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene expression: implications for the pathology of Rieger syndrome. J Cell Biol 152, 545-552, PubMed

122 Wei, Q. and Adelstein, R.S. (2002) Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling. Mol Biol Cell 13, 683-697, PubMed

123 Charles, M.A. et al. (2005) PITX genes are required for cell survival and Lhx3 activation. Mol Endocrinol 19, 1893-1903, PubMed

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