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Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 25; 8 November 2005 Abstract
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Some proposed target genes of PITX2
Tord A. Hjalt and Elena V. Semina
| Table 2. Some proposed target genes of PITX2 | |||
| Gene | Full name | Cell type/organ | Refs |
| PRL | Prolactin | Pituitary | 66 |
| HESX1 | Homeobox gene expressed in ESCs | Pituitary | 73, 91 |
| PROP1 | Prophet of PIT1 | Pituitary | 73, 91 |
| PLOD1 | Pro-collagen lysyl hydroxylase | Eye | 121 |
| TRIO | Triple functional domain | HeLa cells | 122 |
| DLX2 | Distal-less homeobox 2 | Tooth | 81 |
| CYCD2 | Cyclin D2 | Pituitary, heart | 119 |
| ANF/NPPA | Atrial natriuretic factor | Heart | 75 |
| FGF8 | Fibroblast growth factor 8 | Tooth | 94 |
| BMP4 | Bone morphogenetic protein 4 | Tooth | 94 |
| LHX3 | Lim-domain homeobox gene 3 | Pituitary | 123 |
| Abbreviations: ESC, embryonic stem cell; PIT1, pituitary-specific transcription factor 1. | |||
| References cited
in Table 2
66 Szeto, D.P. et al. (1999) Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev 13, 484-494, PubMed 73 Gage, P.J., Suh, H. and Camper, S.A. (1999) Dosage requirement of Pitx2 for development of multiple organs. Development 126, 4643-4651, PubMed 75 Ganga, M. et al. (2003) PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5. J Biol Chem 278, 22437-22445, PubMed 81 Espinoza, H.M. et al. (2002) A molecular basis for differential developmental anomalies in Axenfeld-Rieger syndrome. Hum Mol Genet 11, 743-753, PubMed 91 Lin, C.R. et al. (1999) Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature 401, 279-282, PubMed 94 Liu, W. et al. (2003) Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development 130, 6375-6385, PubMed 119 Kioussi, C. et al. (2002) Identification of a Wnt/Dvl/beta-Catenin > Pitx2 pathway mediating cell-type-specific proliferation during development. Cell 111, 673-685, PubMed 121 Hjalt, T.A., Amendt, B.A. and Murray, J.C. (2001) PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene expression: implications for the pathology of Rieger syndrome. J Cell Biol 152, 545-552, PubMed 122 Wei, Q. and Adelstein, R.S. (2002) Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling. Mol Biol Cell 13, 683-697, PubMed 123 Charles, M.A. et al. (2005) PITX genes are required for cell survival and Lhx3 activation. Mol Endocrinol 19, 1893-1903, PubMed |
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