Guilherme_tab2: Crossreactivity of M-protein-reactive antibodies with human proteins

Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 28; 9 December 2005 Abstract
PDF

Crossreactivity of M-protein-reactive antibodies with human proteins

Luiza Guilherme, Kellen Faé, Sandra E. Oshiro and Jorge Kalil

Author contact details

Table 2. Crossreactivity of M-protein-reactive antibodies with human proteins
M protein	Epitope position	Antibody nature	Crossreactive human proteins	Ref.
M1	13–19	Human	43 kDa kidney protein	39
	23–26		56 kDa kidney protein (vimentin)
	1–12	Murine mAb	None
	13–19		43 kDa protein (kidney/heart)	40
M5	–^a	Rabbit	Sarcolemma	41
	–^a	Rabbit	Cardiac myosin	9
	1–35	Rabbit	None	42
	84–116	Rabbit	Cardiac myosin	43
	164–197	Rabbit	40 kDa heart protein	44
	84–116, 117–134, 164–197	Human mAb	Skeletal muscle myosin, cardiac myosin, actin, keratin	45
	184–197	Murine/human mAb	Cardiac myosin	46
	–^a	Murine mAb	Tropomyosin	10
	–^a	Murine mAb	Valves protein	11
M6	1–20, 10–20, 12–31	Rabbit	None	47
	–^a	Murine mAb	53 kDa glomerular protein	48
	–^a	Human mAb	Skeletal muscle myosin; actin keratin	46
	–^a	Murine mAb	Tropomyosin	10
	223–245,256–277, 240–260, 272–292	Rabbit	Denatured forms of myosin	49
	B repeat region	Rabbit, human	Human brain	50
M12	–^a	Murine mAb	53 kDa glomerular protein	48
M12	1–25	Rabbit	Vimentin (mesangial cells)	51
M19	1–24	Rabbit	60 kDa myocardial protein	52
M24	–^a	Human, rabbit	Brain	53
	S-CB7	Human, rabbit	None	54
	23–35, 18–35, 13–35	Rabbit	None	55
^a Epitope not defined. Abbreviation: mAb, monoclonal antibody.

References cited in Table 2

9 Dale, J.B. and Beachey, E.H. (1985) Epitopes of streptococcal M proteins shared with cardiac myosin. J Exp Med 162, 583-591, PubMed

10 Fenderson, P.G., Fischetti, V.A. and Cunningham, M.W. (1989) Tropomyosin shares immunologic epitopes with group A streptococcal M proteins. J Immunol 142, 2475-2481, PubMed

11 Gulizia, J.M., Cunningham, M.W. and McManus, B.M. (1991) Immunoreactivity of anti-streptococcal monoclonal antibodies to human heart valves. Evidence for multiple cross-reactive epitopes. Am J Pathol 138, 285-301, PubMed

39 Kraus, W. et al. (1989) Autoimmune sequence of streptococcal M protein shared with the intermediate filament protein, vimentin. J Exp Med 169, 481-492, PubMed

40 Kraus, W., Dale, J.B. and Beachey, E.H. (1990) Identification of an epitope of type 1 streptococcal M protein that is shared with a 43-kDa protein of human myocardium and renal glomeruli. J Immunol 145, 4089-4093, PubMed

41 Dale, J.B. and Beachey, E.H. (1985) Multiple, heart-cross-reactive epitopes of streptococcal M proteins. J Exp Med 161, 113-122, PubMed

42 Dale, J.B. and Beachey, E.H. (1986) Localization of protective epitopes of the amino terminus of type 5 streptococcal M protein. J Exp Med 163, 1191-1202, PubMed

43 Dale, J.B. and Beachey, E.H. (1986) Sequence of myosin-crossreactive epitopes of streptococcal M protein. J Exp Med 164, 1785-1790, PubMed

44 Sargent, S.J. et al. (1987) Sequence of protective epitopes of streptococcal M proteins shared with cardiac sarcolemmal membranes. J Immunol 139, 1285-1290, PubMed

45 Cunningham, M.W. et al. (1988) Human monoclonal antibodies reactive with antigens of the group A Streptococcus and human heart. J Immunol 141, 2760-2766, PubMed

46 Cunningham, M.W. et al. (1989) Human and murine antibodies cross-reactive with streptococcal M protein and myosin recognize the sequence GLN-LYS-SER-LYS-GLN in M protein. J Immunol 143, 2677-2683, PubMed

47 Beachey, E.H. and Seyer, J.M. (1986) Protective and nonprotective epitopes of chemically synthesized peptides of the NH2-terminal region of type 6 streptococcal M protein. J Immunol 136, 2287-2292, PubMed

48 Goroncy-Bermes, P. et al. (1987) Monoclonal antibody to human renal glomeruli cross-reacts with streptococcal M protein. Infect Immun 55, 2416-2419, PubMed

49 Vashishtha, A. and Fischetti, V.A. (1993) Surface-exposed conserved region of the streptococcal M protein induces antibodies cross-reactive with denatured forms of myosin. J Immunol 150, 4693-4701, PubMed

50 Bronze, M.S. and Dale, J.B. (1993) Epitopes of streptococcal M proteins that evoke antibodies that cross-react with human brain. J Immunol 151, 2820-2828, PubMed

51 Kraus, W., Seyer, J.M. and Beachey, E.H. (1989) Vimentin-cross-reactive epitope of type 12 streptococcal M protein. Infect Immun 57, 2457-2461, PubMed

52 Bronze, M.S., Beachey, E.H. and Dale, J.B. (1988) Protective and heart-crossreactive epitopes located within the NH2 terminus of type 19 streptococcal M protein. J Exp Med 167, 1849-1859, PubMed

53 Kingston, D. and Glynn, L.E. (1976) Anti-streptococcal antibodies reacting with brain tissue. I. Immunofluourescent studies. Br J Exp Pathol 57, 114-128, PubMed

54 Jolivet, M. et al. (1983) Epitope specific immunity elicited by a synthetic streptococcal antigen without carrier or adjuvant. Biochem Biophys Res Commun 117, 359-366, PubMed

55 Beachey, E.H. et al. (1984) Epitope-specific protective immunogenicity of chemically synthesized 13-, 18-, and 23-residue peptide fragments of streptococcal M protein. Proc Natl Acad Sci U S A 81, 2203-2207, PubMed

| home | search | glossary | links | sitemap | contact |

Expert Reviews in Molecular Medicine © Cambridge University Press ISSN 1462-3994 (Disclaimer and copyright)
Editorial Office: Centre for Applied Research in Educational Technologies (CARET), 1st Floor, 16 Mill Lane, Cambridge, CB2 1SB, UK. Tel: +44 (0)1223 765 375; Fax: +44(0)1223 765 505; E-mail: ermm@caret.cam.ac.uk