Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 7; Issue 29; 20 December 2005 Abstract
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Receptors on T cells and their ligands on antigen-presenting cells

Beverley Wilkinson, Jocelyn S. Downey and Christopher E. Rudd

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Figure 1. Receptors on T cells and their ligands on antigen-presenting cells. T cells express an array of surface receptors that interact with ligands on antigen-presenting cells (APCs). The T-cell receptor (TCR) and associated CD3 subunits (shown in pink) are engaged by a specific peptide antigen presented by the major histocompatibility complex (MHC). CD4 and CD8 bind to non-polymorphic determinants in class II and I antigens, respectively. Co-signals are provided by CD80/CD86 binding to CD28 and CTLA-4, ICOS binding to B7.H, Tim3 binding to Tim3L, SLAM–SLAM binding, PD-1 binding to PDL1/L2, and BTLA binding to HVEM; other interactions such as LFA-1 binding to ICAM-1 and CD2 binding to CD48/58 (not shown) are important for the adhesion between T cells and APCs. Abbreviations: BTLA, B- and T-lymphocyte attenuator; CTLA-4, cytotoxic T-lymphocyte antigen 4; HVEM, herpesvirus entry mediator; ICAM-1, intercellular cell adhesion molecule 1; ICOS, inducible co-stimulator; LFA-1, leukocyte function-associated antigen 1; PD-1, program death 1 receptor; SLAM, signalling lymphocyte activation molecule; Tim3, T-cell immunoglobulin- and mucin-domain-containing molecule 3.

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