Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
DOI: 10.1017/S1462399406000032; 12 July 2006
Surinder M. Soond, David S. Latchman and Anastasis Stephanou (2006) STAT signalling in the heart and cardioprotection. Expert Rev. Mol. Med. Vol. 8, Issue 15, DOI: 10.1017/S1462399406000032

STAT signalling in the heart and cardioprotection

Surinder M. Soond ^{a1 c1}, David S. Latchman a1 and Anastasis Stephanou ^a1

^a1 Institute of Child Health, University College London, London, WC1N 1EH, UK.

^c1 Corresponding author: Surinder M. Soond, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK. Tel: +44 (0)20 7905 2611; Fax: +44 (0)20 7905 2301; E-mail: s.soond@ich.ucl.ac.uk

During the past six years, great progress has been made in defining the key cellular and molecular signalling pathways that determine the fate of cardiac myocytes after ischaemia–reperfusion (IR) and consequently the severity of myocardial infarction. Among the complex network of kinases and transcription factors that mediate signals during IR is the STAT family of ‘signal transducers and activators of transcription’. During IR they are inducibly activated by Janus kinases and have the capability of transcriptionally regulating pro-survival and apoptotic gene expression. In this review we focus on recent progress made in elucidating the regulation and role of the STAT family of proteins during cardioprotective signalling events in myocardial preconditioning and during IR injury in cardiac myocyte cells and the myocardium. Moreover, we also highlight developments in understanding how this signalling pathway might be amenable to therapeutic intervention, permitting cardiac myocyte survival following IR.

Full text online (purchase or subscribe through Cambridge Journals Online)

| home | search | glossary | links | sitemap | contact |

Expert Reviews in Molecular Medicine © Cambridge University Press ISSN 1462-3994 (Disclaimer and copyright)
Editorial Office: Centre for Applied Research in Educational Technologies (CARET), 1st Floor, 16 Mill Lane, Cambridge, CB2 1SB, UK. Tel: +44 (0)1223 765 375; Fax: +44(0)1223 765 505; E-mail: ermm@caret.cam.ac.uk