Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
DOI: 10.1017/S1462399406000093; 18 September 2006
Alison Brewer and John Pizzey (2006) GATA factors in vertebrate heart development and disease. Expert Rev. Mol. Med. Vol. 8, Issue 22, DOI: 10.1017/S1462399406000093

GATA factors in vertebrate heart development and disease

Alison Brewer ^a1 and John Pizzey ^{a2 c1}

^a1 Cardiovascular Division, Department of Cardiology, King's College London School of Medicine, London, SE5 9PJ, UK

^a2 Wolfson Centre for Age-related Diseases, King's College London, Hodgkin Building, Guy's Campus, London, SE1 1UL, UK

^c1 Corresponding author: John Pizzey, Wolfson Centre for Age-related Diseases, King's College London, Hodgkin Building, Guy's Campus, London, SE1 1UL, UK. Tel: +44 (0)20 7848 6461; Fax: +44 (0)20 7848 6569; E-mail: john.pizzey@kcl.ac.uk

Vertebrate heart formation is dependent upon complex hierarchical gene regulatory networks, which effect both the specification and differentiation of cardiomyocytes and subsequently cardiac morphogenesis. GATA-4, -5 and -6 comprise an evolutionarily conserved subfamily of transcription factors, which are expressed within the precardiac mesoderm from early stages in its specification and continue to be expressed within the adult heart. We review here the functional roles of individual GATA transcription factors in cardiac development, normal homeostasis and disease. We also review the cellular mechanisms employed to regulate the expression and downstream targets of the different GATA factors.

Full text online (purchase or subscribe through Cambridge Journals Online)

| home | search | glossary | links | sitemap | contact |

Expert Reviews in Molecular Medicine © Cambridge University Press ISSN 1462-3994 (Disclaimer and copyright)
Editorial Office: Centre for Applied Research in Educational Technologies (CARET), 1st Floor, 16 Mill Lane, Cambridge, CB2 1SB, UK. Tel: +44 (0)1223 765 375; Fax: +44(0)1223 765 505; E-mail: ermm@caret.cam.ac.uk