Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
DOI: 10.1017/S1462399406000172; 11 December 2006
Bedrick B. Gadea and Johanna A. Joyce (2006) Tumour–host interactions: implications for developing anti-cancer therapies. Expert Rev. Mol. Med. Vol. 8, Issue 30, DOI: 10.1017/S1462399406000172

Tumour–host interactions: implications for developing anti-cancer therapies

Bedrick B. Gadea ^a1 and Johanna A. Joyce ^{a1 c1}

^a1 Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.

^c1 Corresponding author: Johanna A. Joyce, Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Box 372, New York, NY 10021, USA. Tel: +1 646 888 2048; Fax: +1 646 422 0231; E-mail: joycej@mskcc.org

Cancers are a complex set of proliferative diseases that arise in most cases through multi-step pathways involving an accumulation of genetic and epigenetic changes. These steps include inactivation of tumour suppressor genes and activation of oncogenes. However, in addition to genetic mutations in the tumour cells themselves, the local host environment can act as a critical modulator of cancer progression, having either tumour-suppressive or tumour-promoting effects depending on the stage and site of cancer development. Because stromal cells can have these opposing functions during cancer development and progression, a recurring theme throughout this review will be that of balance: maintaining the normal functions of these co-opted cells, yet selectively inhibiting their pro-tumourigenic functions. To achieve this equilibrium, we need to understand the molecular mechanisms by which normal cells become modified by cancer cells before we can hope to target these functions selectively. Here, we will discuss recent efforts to address these key challenges and offer perspectives on the translation of discoveries made in model systems to the clinic.

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