Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 2; 17 January 2006 Abstract
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The primary cilium

Bradley K. Yoder, Sharon Mulroy, Hannah Eustace, Catherine Boucher and Richard Sandford

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Figure 6. The primary cilium. (a) Confocal micrographs of the primary cilium of renal tubular epithelial cells stained with (1) a cilial marker, (2) polycystin-2 and (3) the merged image, demonstrating the presence of a single cilia arising from the surface of each cell and the expression of the polycystins in the cilia (1000X). (b) A simplified schematic representation of the primary cilium. The central microtubular axoneme of the primary cilium is seen arising from the basal body, which is derived from the centrioles. Cilial proteins such as the polycystins are transported along the cilia in intraflagellar transport (IFT) particles by the kinesin motor protein. IFT particles are also transported back towards the cell body after delivering their cargo. (c) Cross-section of the cilium, demonstrating the ‘9+0’ axoneme structure of the nonmotile cilia.

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