Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 3; 27 January 2006 Abstract
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L-arginine depletion generates superoxide by uncoupling of eNOS

Sowndramalingam Sankaralingam, Ivan A. Arenas, Manoj M. Lalu and Sandra T. Davidge

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Figure 2. L-arginine depletion generates superoxide by uncoupling of eNOS. Endothelial nitric oxide synthase (eNOS) catalyses the conversion of L-arginine to nitric oxide (NO) and L-citrulline. An upregulation of arginase results in depletion of L-arginine and causes uncoupling of eNOS to generate superoxide anions (O₂^.–), which subsequently scavenge NO to generate peroxynitrite (ONOO^–).

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