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Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 4; 7 February 2006 Abstract
PDF
GLUT1 susceptibility alleles for diabetic nephropathy
Charles W. Heilig, Frank C. Brosius III and Carol Cunningham
| Table 2. GLUT1 susceptibility alleles for diabetic nephropathya | |||||
| Study | Diabetes | Race, country | Patient numbers: controls versus diabetics | GLUT1 SNPb | Association of SNP with nephropathy |
| Gutierrez et al. (Ref. 78) | Type 2 | Caucasian, Spain | 100 vs 20 | XbaI | No |
| Liu et al. (Ref. 74) | Type 2 | Asian, China | 45 vs 64 | XbaI | Yes |
| Grzeszczak et al. (Ref. 75) | Type 2 | Caucasian, Poland | 162 vs 132 | XbaI | Yes |
| Hodgkinson et al. (Ref. 73) | Type 1 | Caucasian, UK | 44 vs 70 | XbaI | Yes |
| Tarnow et al. (Ref. 79) | Type 1 | Caucasian, Denmark | 192 vs 175 | XbaI | No |
| Ng et al. (Ref. 76) | Type 1 | Caucasian, USA | 207 vs 249 | XbaI Enh2SNP1 |
Yes Yes |
| Hodgkinson et al. (Ref. 22) | Type 1 | Caucasian, UK | 101 vs 288 | A–2841T | Yes |
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a
Diabetic nephropathy was defined in these studies as persistent albuminuria
or chronic renal failure. |
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References cited in Table 2 22 Hodgkinson, A.D. et al. (2005) A novel polymorphism in the 5' flanking region of the glucose transporter (GLUT1) gene is strongly associated with diabetic nephropathy in patients with Type 1 diabetes mellitus. J Diabetes Complications 19, 65-69, PubMed 73 Hodgkinson, A.D., Millward, B.A. and Demaine, A.G. (2001) Polymorphisms of the glucose transporter (GLUT1) gene are associated with diabetic nephropathy. Kidney Int 59, 985-989, PubMed 74 Liu, Z.H. et al. (1999) Glucose transporter (GLUT1) allele (XbaI-) associated with nephropathy in non-insulin-dependent diabetes mellitus. Kidney Int 55, 1843-1848, PubMed 75 Grzeszczak, W. et al. (2001) Role of GLUT1 gene in susceptibility to diabetic nephropathy in type 2 diabetes. Kidney Int 59, 631-636, PubMed 76 Ng, D.P. et al. (2002) Minor effect of GLUT1 polymorphisms on susceptibility to diabetic nephropathy in type 1 diabetes. Diabetes 51, 2264-2269, PubMed 78 Gutierrez, C. et al. (1998) GLUT1 gene polymorphism in non-insulin-dependent diabetes mellitus: genetic susceptibility relationship with cardiovascular risk factors and microangiopathic complications in a Mediterranean population. Diabetes Res Clin Pract 41, 113-120, PubMed 79 Tarnow, L. et al. (2001) Diabetic microvascular complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients. Nephrol Dial Transplant 16, 1653-1656, PubMed |
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