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Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 5; 6 March 2006 Abstract
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Overview of lytic replication of the Epstein–Barr virus genome
Alison Sinclair, Sarah Yarranton and Celine Schelcher
Figure 2. Overview of lytic replication of the Epstein–Barr virus genome. Epstein–Barr virus (EBV) virions contain a double-stranded linear DNA genome. Upon infection of permissive cells, the double-stranded linear DNA is converted to circular double-stranded DNA by association of the terminal repeats (TRs). This episome form of the genome replicates once per cell division in latently infected cells (not shown), using the origin of replication OriP. Following the binding of the lytic switch transactivator Zta to the alternative replication origin OriLyt, a rolling-circle replication occurs, generating multiple copies of the linear genome. In the figure, new DNA synthesis is shown by the grey arrows. The new DNA is cut at each TR, releasing single genome-length units, which are packaged and released from the cell.
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