Sinclair_tab1: Overview of the components of the DNA damage responses to single-strand and double-strand breaks

Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 5; 6 March 2006 Abstract
PDF

Overview of lytic replication of the Epstein–Barr virus genome

Alison Sinclair, Sarah Yarranton and Celine Schelcher

Author contact details

Table 1. Overview of the components of the DNA damage responses to single-strand and double-strand breaks^a
DNA damage	DNA repair pathway	Sensors	Transducers	Effectors	Cellular effects
SSBs	ATR	ATRIP	ATR	H2AX	Cell cycle arrest
		Rad17–RFC complex	Chk1	p53	DNA repair
			BRCA1	p21
				Smc1
DSBs	ATM	p53BP1	ATM	H2AX	Cell cycle arrest
		MRN complex	Chk1	p53	DNA repair
			Chk2	p21	Apoptosis
				53BP1
				Mdm2
				Smc1
				Cdc25 A and C
				E2F1
	DNA-PK	Ku heterodimer	ATM	H2AX	Cell cycle arrest
			DNA-PK	p53	DNA repair
			Artemis	p21	Apoptosis
				Mdm2
				MRN complex
				XRCC4
				Ligase IV
^a For references, see 7, 8, 9, 10, 12. Abbreviations: ATM, ataxia-telengiectasia mutated; ATR, ataxia-telengiectasia and Rad3-related; ATRIP, ATR-interacting protein; BRCA1, breast cancer type 1 susceptibility protein; Cdc25, cell division cycle 25; Chk, checkpoint homologue; DNA-PK, DNA-dependent protein kinase; DSBs, double-strand DNA breaks; E2F1, E2F transcription factor 1; H2AX, H2A histone family, member X; Mdm2, double minute 2 gene product; MRN complex, a complex of the nuclease Mre11, the DNA-binding protein Rad50 and the Nijmegen breakage syndrome 1 gene product Nbs1; 53BP1, p53-binding protein 1; Rad17, a post-replication repair protein; RFC, replication factor complex; Smc1, structural maintenance of chromosomes 1; SSBs, single-strand DNA breaks; XRCC4, X-ray repair complementing defective repair in Chinese hamster cells 4.

References cited in Table 1

7 Bartek, J. and Lukas, J. (2001) Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol 13, 738-747, PubMed

8 Rouse, J. and Jackson, S.P. (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297, 547-551, PubMed

9 Zhou, B.B., Mattern, M.R. and Khanna, K.K. (2003) Role of tumor suppressors in DNA damage response. Methods Mol Biol 223, 39-50, PubMed

10 Lobrich, M. and Jeggo, P.A. (2005) The two edges of the ATM sword: co-operation between repair and checkpoint functions. Radiother Oncol 76, 112-118, PubMed

12 Nyberg, K.A. et al. (2002) Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet 36, 617-656, PubMed

| home | search | glossary | links | sitemap | contact |

Expert Reviews in Molecular Medicine © Cambridge University Press ISSN 1462-3994 (Disclaimer and copyright)
Editorial Office: Centre for Applied Research in Educational Technologies (CARET), 1st Floor, 16 Mill Lane, Cambridge, CB2 1SB, UK. Tel: +44 (0)1223 765 375; Fax: +44(0)1223 765 505; E-mail: ermm@caret.cam.ac.uk