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Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 6; 24 March 2006 Abstract
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Mechanisms leading to anaemia in malaria
Tracey J. Lamb, Douglas E. Brown, Alexandre J. Potocnik and Jean Langhorne
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Table 2. Mechanisms leading to anaemia in malaria |
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| Mechanism | Details | Refs |
| Destruction of pRBCs | Haemolysis: parasite
maturation, haemoglobin metabolism by
the parasite Immune recognition: parasite antigen present on RBC surface |
162 |
| Destruction of npRBCs | Reticuloendothelial
hyperplasia: increased removal of RBCs from
circulation Immune recognition: uptake of circulating parasite antigen by npRBCs |
163, 164 |
| Erythropoietic suppression | Decreased RBC production resulting from pro-inflammatory cytokine production, reduced response to EPO, other factors? | 162 |
| Dyserythropoiesis | Abnormal Fe2+ incorporation, inefficient maturation | 162 |
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Abbreviations: EPO, erythropoietin; npRBC, non-parasitised red blood cell; pRBC, parasitised red blood cell. |
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| References cited
in Table 2
162 Chang, K.H. and Stevenson, M.M. (2004) Malarial anaemia: mechanisms and implications of insufficient erythropoiesis during blood-stage malaria. Int J Parasitol 34, 1501-1516, PubMed 163 Howard, R.J. and Mitchell, G.F. (1979) Accelerated clearance of uninfected red cells from Plasmodium berghei-infected mouse blood in normal mice. Aust J Exp Biol Med Sci 57, 455-457, PubMed 164 Hunter, K.W., Jr., Winkelstein, J.A. and Simpson, T.W. (1979) Serum opsonic activity in rodent malaria: functional and immunochemical characteristics in vitro. J Immunol 123, 2582-2587, PubMed |
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