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Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 9; 28 April 2006 Abstract
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Scanning electron micrographs showing morphological changes in red blood cells in sickle cell anaemia

Catherine Madigan and Punam Malik

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Figure 1. Scanning electron micrographs showing morphological changes in red blood cells in sickle cell anaemia. Upon deoxygenation, red blood cells (RBCs) convert from the biconcave disc to the rigid, sickle form. (a) An oxygenated RBC from a patient with sickle cell anaemia. (b) The same cell after undergoing deoxygenation. Images reproduced from http://history.nih.gov/exhibits/genetics/images/sect1/6ajpg.htm, courtesy of the National Institutes of Health, and Dr Alan N. Schechter, National Institute of Diabetes and Digestive and Kidney Diseases.

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