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Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 9; 28 April 2006 Abstract
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Key molecules that mediate RBC adhesion in sickle cell disease

Catherine Madigan and Punam Malik

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Table 2. Key molecules that mediate RBC adhesion in sickle cell disease

RBC adhesion molecule

Ligand Refs
von Willebrand factor GPIIb, avb3 185, 186, 187
CD36 Thrombospondin 188
CD47 a5b3 189

a4b1

VCAM-1, fibronectin

44
BCAM/Lutheran Laminin (ECM) 45, 190

Phosphatidyl serine

a5b3 41
Abbreviations: BCAM, basal cell adhesion molecule; CD36, platelet glycoprotein IV; CD47, integrin-associated protein; ECM, extracellular matrix; GP, glycoprotein; RBC, red blood cell; VCAM, vascular cell adhesion molecule.

References cited in Table 2

41 Setty, B.N., Kulkarni, S. and Stuart, M.J. (2002) Role of erythrocyte phosphatidylserine in sickle red cell-endothelial adhesion. Blood 99, 1564-1571, PubMed

44 Swerlick, R.A. et al. (1993) Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium. Blood 82, 1891-1899, PubMed

45 Zen, Q. et al. (2004) B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. Am J Hematol 75, 63-72, PubMed

185 Wick, T.M. et al. (1987) Unusually large von Willebrand factor multimers increase adhesion of sickle erythrocytes to human endothelial cells under controlled flow. J Clin Invest 80, 905-910, PubMed

186 Cheresh, D.A. (1987) Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc Natl Acad Sci U S A 84, 6471-6475, PubMed

187 Lawler, J., Weinstein, R. and Hynes, R.O. (1988) Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. J Cell Biol 107, 2351-2361, PubMed

188 Joneckis, C.C. et al. (1993) Integrin alpha 4 beta 1 and glycoprotein IV (CD36) are expressed on circulating reticulocytes in sickle cell anemia. Blood 82, 3548-3555, PubMed

189 Manodori, A.B. et al. (2000) Adherence of phosphatidylserine-exposing erythrocytes to endothelial matrix thrombospondin. Blood 95, 1293-1300, PubMed

190 Udani, M., Rao, N. and Telen, M.J. (1997) Leukocyte phenotypic changes in an in vitro model of ABO hemolytic transfusion reaction. Transfusion 37, 904-909, PubMed


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