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Accession information: Vol. 8; Issue 9; 28 April 2006 Abstract
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Key molecules that mediate RBC adhesion in sickle cell disease
Catherine Madigan and Punam Malik
| Table 2. Key molecules that mediate RBC adhesion in sickle cell disease | ||
|
RBC adhesion molecule |
Ligand | Refs |
| von Willebrand factor | GPIIb, avb3 | 185, 186, 187 |
| CD36 | Thrombospondin | 188 |
| CD47 | a5b3 | 189 |
|
a4b1 |
VCAM-1, fibronectin |
44 |
| BCAM/Lutheran | Laminin (ECM) | 45, 190 |
|
Phosphatidyl serine |
a5b3 | 41 |
| Abbreviations: BCAM, basal cell adhesion molecule; CD36, platelet glycoprotein IV; CD47, integrin-associated protein; ECM, extracellular matrix; GP, glycoprotein; RBC, red blood cell; VCAM, vascular cell adhesion molecule. | ||
|
References cited
in Table 2 44 Swerlick, R.A. et al. (1993) Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium. Blood 82, 1891-1899, PubMed 45 Zen, Q. et al. (2004) B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. Am J Hematol 75, 63-72, PubMed 185 Wick, T.M. et al. (1987) Unusually large von Willebrand factor multimers increase adhesion of sickle erythrocytes to human endothelial cells under controlled flow. J Clin Invest 80, 905-910, PubMed 186 Cheresh, D.A. (1987) Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc Natl Acad Sci U S A 84, 6471-6475, PubMed 187 Lawler, J., Weinstein, R. and Hynes, R.O. (1988) Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. J Cell Biol 107, 2351-2361, PubMed 188 Joneckis, C.C. et al. (1993) Integrin alpha 4 beta 1 and glycoprotein IV (CD36) are expressed on circulating reticulocytes in sickle cell anemia. Blood 82, 3548-3555, PubMed 189 Manodori, A.B. et al. (2000) Adherence of phosphatidylserine-exposing erythrocytes to endothelial matrix thrombospondin. Blood 95, 1293-1300, PubMed 190 Udani, M., Rao, N. and Telen, M.J. (1997) Leukocyte phenotypic changes in an in vitro model of ABO hemolytic transfusion reaction. Transfusion 37, 904-909, PubMed |
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