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Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 9; 28 April 2006 Abstract
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Points of impact of hydroxyurea
Catherine Madigan and Punam Malik
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Table 3. Points of impact of hydroxyurea |
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Hydroxyurea effects |
Impact on sickle cell disease | Refs |
| Increased HbF production | Prevention of sickle polymer formation | 106, 107, 108 |
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Increased MCV |
Decreased HbS concentration | 126 |
| Improved haemoglobin | Amelioration of anaemia and hypoxia | 106, 133 |
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Myelosuppression |
Decreased leukocyte production, decreased inflammation |
191 |
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NO production |
Vasodilation and improved blood flow | 130, 131, 132 |
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Decreased adhesion molecules |
Decreased RBC adherence and improved blood flow | 127, 129 |
| Abbreviations: Hb, haemoglobin; MCV, mean corpuscular volume; NO, nitric oxide; RBC, red blood cell. | ||
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References cited
in Table 3 107 Charache, S. et al. (1992) Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia. Blood 79, 2555-2565, PubMed 108 Charache, S. et al. (1987) Hydroxyurea-induced augmentation of fetal hemoglobin production in patients with sickle cell anemia. Blood 69, 109-116, PubMed 126 Orringer, E.P. et al. (1991) Effects of hydroxyurea on hemoglobin F and water content in the red blood cells of dogs and of patients with sickle cell anemia. Blood 78, 212-216, PubMed 127 Styles, L.A. et al. (1997) Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea. Blood 89, 2554-2559, PubMed 129 Adragna, N.C., Fonseca, P. and Lauf, P.K. (1994) Hydroxyurea affects cell morphology, cation transport, and red blood cell adhesion in cultured vascular endothelial cells. Blood 83, 553-560, PubMed 130 Sato, K. et al. (1997) Nitric oxide generation from hydroxyurea via copper-catalyzed peroxidation and implications for pharmacological actions of hydroxyurea. Jpn J Cancer Res 88, 1199-1204, PubMed 131 Pacelli, R. et al. (1996) Hydroxyurea reacts with heme proteins to generate nitric oxide. Lancet 347, 900, PubMed 132 Jiang, J. et al. (1997) In vivo production of nitric oxide in rats after administration of hydroxyurea. Mol Pharmacol 52, 1081-1086, PubMed 133 Kinney, T.R. et al. (1999) Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. Blood 94, 1550-1554, PubMed 191 Charache, S. et al. (1996) Hydroxyurea and sickle cell anemia. Clinical utility of a myelosuppressive "switching" agent. The Multicenter Study of Hydroxyurea in Sickle Cell Anemia. Medicine (Baltimore) 75, 300-326, PubMed |
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