Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 7; 11 April 2006 Abstract
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Cellular targets and functions of anthrax toxin

David J. Banks, Sabrina C. Ward and Kenneth A. Bradley

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Figure 2. Cellular targets and functions of anthrax toxin. (a) Neutrophils. Lethal toxin (LT) and oedema toxin (OT) inhibit neutrophil mobility and phagocytosis, respectively. (b) Macrophages and dendritic cells (DCs). LT and OT kill and modulate various immune cells at distinct states of activation and differentiation (see Table 1). (c) Endothelial cells and red blood cells. LT and OT cause endothelial cell (EC) barrier dysregulation, coagulopathy, red blood cell (RBC) death, direct and indirect EC death, and EC cytokine transcript modulation. Black T-bars indicate inhibition or modulation; red T-bars indicate cell death; shaded arrow indicates mobility; grey arrow indicates DC-mediated T-cell activation.

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