Morrison_tab1: Pathological features seen in amyotrophic lateral sclerosis

Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 11; 24 May 2006 Abstract
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Pathological features seen in amyotrophic lateral sclerosis

Emily F. Goodall and Karen E. Morrison

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Table 1. Pathological features seen in amyotrophic lateral sclerosis
Feature	Description/location
Loss of motor neurons	Evident in cortex, brain stem and spinal cord
Axonal spheroids	Neurofilament aggregates in proximal axons of motor neurons
Bunina bodies	Eosinophilic bodies found in the soma of anterior horn cells; these are unique to amyotrophic lateral sclerosis
Ubiquitinated inclusions ‘Skein-like’ inclusions ‘Lewy body-like’ inclusions	Predominantly found in lower motor neurons Threads/filamentous bodies Compact, dense bodies
Hyaline inclusions	Large aggregates containing neurofilaments and other entrapped proteins in the soma of motor neurons

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