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Expert
Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 8; Issue 13; 12 June 2006 Abstract
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Location of some weak-D-causative amino acid polymorphisms
Neil D. Avent, Tracey E. Madgett, Zoe E. Lee, David J. Head, Deborah G. Maddocks and Lucy H. Skinner
Figure 3. Location of some weak-D-causative amino acid polymorphisms. The figure depicts the membrane localisation of amino acids known to cause weak D phenotypes: most are found in membrane helices and their side-chains may be involved in formation of the Rh trimer complex. Helices are shown as blue and white ribbons, and exoloops at the top and endoloops at the bottom are shown in green. The side-chains of the RhD amino acids altered in the weak D phenotype are illustrated in blue. The side-chains of exofacial amino acids S103 (loop 2), E233 (loop 4) and G353 (loop 6) are shown in yellow. The following mutations are highlighted: Weak D Type 1, V270G; Type 2, G385A; Type 4, T201R, F223V; Type 5, A149D; Type 7, G339E; Type 8, G307R; Type 9, A294P; Type 10, W393R; Type 11, M295I; Type 12, G277E. The RhD structure was modelled using the DeepView-Swiss PdbViewer.
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