fig002cso: Activation of pp60c-src kinase

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Accession information: (99)00064-2h.htm (shortcode: fig002cso); 4 May 1999
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Activation of pp60^c-src kinase

Christopher M. Sanderson and Geoffrey L. Smith

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Figure 2. Activation of pp60^c-src kinase. The inactive form of pp60c-src kinase is phosphorylated at Tyr527, promoting interaction between the carboxyl-terminal tail and the SH2 domain. De-phosphorylation of Tyr527 results in structural rearrangement and activation of kinase activity. Because Tyr527 is deleted in v-src, pp60^v-src is constitutively active (fig002cso).

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