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T cells from tolerant mice control the rejection that is mediated by naive cells from the recipient strain
Andrew Bushell and Kathryn J. Wood
Figure 4. T cells from tolerant mice control the rejection that is mediated by naive cells from the recipient strain. (a) Tolerance to a skin graft (which was mismatched with the recipient for multiple minor transplantation antigens) can be induced by removal of the thymus (thymectomy), followed by administration of non-depleting anti-CD4 antibodies plus anti-CD8 antibodies. (b) T cells that were harvested from mice with long-term surviving grafts and then transferred to ‘test-tube’ mice (i.e. mice with no T cells of their own) prevent naive cells from rejecting a fresh skin graft (naive cells are those that have no ‘experience’ of the antigens in question). Such results suggest that the tolerant mice contain regulatory cells that are capable of suppressing naive T-cell responses (fig004abo).
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