(1) KCNQ2; 20q (EBN1); KCNQ2, a voltage-gated K⁺ ion channel.
(2) KCNQ3; 8q24 (EBN2); KCNQ3, a voltage-gated K⁺ ion channel.

15
16
22

Generalised epilepsy with febrile seizures plus (GEFS+)
Autosomal dominant.

(1) SCN1B; 19q13 (GEFS1); b1 subunit of voltage-gated Na⁺ ion channel.
(2) Unknown; chromosome 2; unknown.

(1) ?CHRNA7; 15q14; a7 subunit of nAChR.
(2) With or without idiopathic generalised epilepsy: unknown; 6p (EJM1); unknown.

41
42
43
44
45
46
47

(1) (In minority only) CHRNA4; 20q13.2–q13.3; a4 subunit of nAChR.
(2) Unknown; 15q24, possibly close to the CHRNA3–CHRNA5–CHRNB4 region; unknown.
(3) Other unknown genes.

4
5
11

Onset at 8–19 years of age; infrequent partial seizures with or without non-specific auditory disturbances.

Onset at 3.5–12 months of age; partial motor seizures with secondary generalisation.

Benign rolandic epilepsy (also known as benign epilepsy with centrotemporal spikes)
Complex inheritance.

Onset at 2–14 years of age; partial motor seizures with or without secondary generalisation; inter-ictal EEG characterised by centrotemporal spikes.

References cited in Table 1

4 Steinlein, O.K. et al. (1995) A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat Genet 11, 201-203, PubMed

5 Steinlein, O.K. et al. (1997) An insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsy. Hum Mol Genet 6, 943-947, PubMed

11 Phillips, H.A. et al. (1998) Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24. Am J Hum Genet 63, 1108-1116, PubMed

15 Biervert, C. et al. (1998) A potassium channel mutation in neonatal human epilepsy. Science 279, 403-406, PubMed

16 Singh, N.A. et al. (1998) A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet 18, 25-29, PubMed

22 Charlier, C. et al. (1998) A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet 18, 53-55, PubMed

30 Lopes-Cendes, I., Lopes-Cendes, I. and Lopes-Cendes, I. (1996) Mapping a locus for idiopathic epilepsy in a large multiplex family. Epilepsia 37(S5), 127

31 Wallace, R.H. et al. (1998) Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nat Genet 19, 366-370, PubMed

41 Greenberg, D.A. et al. (1988) Juvenile myoclonic epilepsy (JME) may be linked to the BF and HLA loci on human chromosome 6. Am J Med Genet 31, 185-192, PubMed

42 Durner, M. et al. (1991) Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients. Neurology 41, 1651-1655, PubMed

43 Weissbecker, K.A. et al. (1991) Confirmation of linkage between juvenile myoclonic epilepsy locus and the HLA region of chromosome 6. Am J Med Genet 38, 32-36, PubMed

44 Liu, A.W. et al. (1995) Juvenile myoclonic epilepsy locus in chromosome 6p21.2-p11: linkage to convulsions and electroencephalography trait. Am J Hum Genet 57, 368-381, PubMed

45 Whitehouse, W.P. et al. (1993) Linkage analysis of idiopathic generalized epilepsy (IGE) and marker loci on chromosome 6p in families of patients with juvenile myoclonic epilepsy: no evidence for an epilepsy locus in the HLA region. Am J Hum Genet 53, 652-662, PubMed

46 Elmslie, F.V. et al. (1996) Linkage analysis of juvenile myoclonic epilepsy and microsatellite loci spanning 61 cM of human chromosome 6p in 19 nuclear pedigrees provides no evidence for a susceptibility locus in this region. Am J Hum Genet 59, 653-663, PubMed

47 Elmslie, F.V. et al. (1997) Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q. Hum Mol Genet 6, 1329-1334, PubMed

49 Neubauer, B.A. et al. (1998) Centrotemporal spikes in families with rolandic epilepsy: linkage to chromosome 15q14. Neurology 51, 1608-1612, PubMed

87 Fong, G.C. et al. (1998) Childhood absence epilepsy with tonic-clonic seizures and electroencephalogram 3-4-Hz spike and multispike-slow wave complexes: linkage to chromosome 8q24. Am J Hum Genet 63, 1117-1129, PubMed

88 Ottman, R. et al. (1995) Localization of a gene for partial epilepsy to chromosome 10q. Nat Genet 10, 56-60, PubMed

89 Guipponi, M. et al. (1997) Linkage mapping of benign familial infantile convulsions (BFIC) to chromosome 19q. Hum Mol Genet 6, 473-477, PubMed