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Review articles

new.gif (987 bytes) Molecular medicine of microRNAs: structure, function and implications for diabetes
Erica Hennessy and Lorraine O'Driscoll
Abstract
Published 15th August 2008

new.gif (987 bytes) New molecular targets in angiogenic vessels of glioblastoma tumours
Joshua C. Anderson, Braden C. McFarland and Candece L. Gladson
Abstract
Published 7th August 2008

new.gif (987 bytes) Critical molecular abnormalities in high-grade serous carcinoma of the ovary
Martin Köbel, David Huntsman and C. Blake Gilks
Abstract
Published 1st August 2008

Molecular pathogenesis and clinical implications of eczema herpeticum
Caroline Bussmann, Wen-Ming Peng, Thomas Bieber and Natalija Novak
Abstract
Published 14th July 2008

CD1d-restricted glycolipid antigens: presentation principles, recognition logic and functional consequences
William C. Florence, Rakesh K. Bhat and Sebastian Joyce
Abstract
Published 7th July 2008

p21 and p27: roles in carcinogenesis and drug resistance
Abde M. Abukhdeir and Ben Ho Park
Abstract
Published 1st July 2008

Therapeutic immunomodulators from nematode parasites
William Harnett and Margaret M. Harnett
Abstract
Published 19th June 2008

Galectins: structure, function and therapeutic potential
Ri-Yao Yang, Gabriel A. Rabinovich and Fu-Tong Liu
Abstract
Published 13th June 2008

Advances in mouse models of prostate cancer
Imran Ahmad, Owen J. Sansom and Hing Y. Leung
Abstract
Published 9th June 2008

Mechanisms in allergic airway inflammation – lessons from studies in the mouse
Bennett O.V. Shum, Michael S. Rolph and William A. Sewell
Abstract
Published 27th May 2008

The molecular and cellular defects underlying Pelizaeus–Merzbacher disease
Karen J. Woodward
Abstract
Published 19th May 2008

Mammalian aquaporins: diverse physiological roles and potential clinical significance
A. S. Verkman
Abstract
Published 16th May 2008

Molecular mechanisms of antibody-mediated neutralisation of flavivirus infection
Theodore C. Pierson and Michael S. Diamond
Abstract
Published 12th May 2008

Wound healing and local neuroendocrine regulation in the injured liver
Mohammad R. Ebrahimkhani, Ahmed M. Elsharkawy and Derek A. Mann
Abstract
Published 29th April 2008

Interrogating the genome to understand oestrogen-receptor-mediated transcription
Sara C. Dietz and Jason S. Carroll
Abstract
Published 1st April 2008

Molecular pathogenesis of intrahepatic cholestasis of pregnancy
Marco Arrese, Rocio I.R. Macias, Oscar Briz, Maria J. Perez and Jose J.G. Marin
Abstract
Published 28th March 2008

Protein–protein interactions as targets for small-molecule therapeutics in cancer
Alex W. White, Andrew D. Westwell and Ghali Brahemi
Abstract
Published 19th March 2008

Molecular mechanisms and treatment of bone metastasis
Gregory A. Clines and Theresa A. Guise
Abstract
Published 6th March 2008

BRAF kinase in melanoma development and progression
Amena M. DeLuca, Archana Srinivas and Rhoda M. Alani
Abstract
Published 18th February 2008

Rotavirus vaccines: how they work or don't work
Richard L. Ward
Abstract
Published 12th February 2008

Mammalian target of rapamycin (mTOR) pathway signalling in lymphomas
Elias Drakosa, George Z. Rassidakisa and L. Jeffrey Medeiros
Abstract
Published 4th February 2008

Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications
Evanthia Diamanti-Kandarakis
Abstract
Published 30th January 2008

Targeting of the immune system in systemic lupus erythematosus
Meera Ramanujam and Anne Davidson
Abstract
Published 21st January 2008

The mucopolysaccharidoses: a success of molecular medicine
Lorne A. Clarke
Abstract
Published 18th January 2008

2007

Virulence factors in brucellosis: implications for aetiopathogenesis and treatment
Emilie Fugier, Georgios Pappas and Jean-Pierre Gorvel
Abstract
Published 19th December 2007

Antibody-based immunotherapy in high-risk neuroblastoma
Erik Johnson, Shannon M. Dean and Paul M. Sondel
Abstract
Published 17th December 2007

Iron-regulatory proteins: molecular biology and pathophysiological implications
Gaetano Cairo and Stefania Recalcati
Abstract
Published 5th December 2007

Pathogenesis of infantile haemangioma: new molecular and cellular insights
Matthew R. Ritter, Ross A. Butschek, Martin Friedlander and Sheila F. Friedlander
Abstract
Published 29th November 2007

Stem cell ageing: does it happen and can we intervene?
Ilaria Bellantuono and W. Nicol Keith
Abstract
Published 19th November 2007

New targeted therapies for treatment of thrombosis in antiphospholipid syndrome
Silvia S. Pierangeli, Mariano E. Vega-Ostertag and Emilio B. González
Abstract
Published 13th November 2007

Haematopoietic stem cell transplantation: can our genes predict clinical outcome?
Anne M. Dickinson, Jane L. Harrold and Hannah Cullup
Abstract
Published 2nd November 2007

Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression
Mandi Murph and Gordon B. Mills
Abstract
Published 15th October 2007

The molecular pathogenesis of Paget disease of bone
Robert Layfield
Abstract
Published 1st October 2007

Holoprosencephaly: new models, new insights
Robert S. Krauss
Abstract
Published 24th September 2007

Charcot–Marie–Tooth type 4B demyelinating neuropathy: deciphering the role of MTMR phosphatases
Stefano C. Previtali, Angelo Quattrini and Alessandra Bolino
Abstract
Published 20th September 2007

Autism: the quest for the genes
Nuala H. Sykes and Janine A. Lamb
Abstract
Published 3rd September 2007

Rubinstein–Taybi syndrome: clinical and molecular overview
Jeroen H. Roelfsema and Dorien J.M. Peters
Abstract
Published 20th August 2007

Congenital myasthenic syndromes: spotlight on genetic defects of neuromuscular transmission
Juliane S. Müller, Violeta Mihaylova, Angela Abicht and Hanns Lochmüller
Abstract
Published 9th August 2007

Molecular cell biology of KATP channels: implications for neonatal diabetes
Andrew J. Smith, Tarvinder K. Taneja, Jamel Mankouri and Asipu Sivaprasadarao
Abstract
Published 1st August 2007

Molecular targets for disrupting leukocyte trafficking during multiple sclerosis
Erin E. McCandless and Robyn S. Klein
Abstract
Published 19th July 2007

Norovirus–host interaction: implications for disease control and prevention
Ming Tan and Xi Jiang
Abstract
Published 11th July 2007

Salmonella-induced enteritis: molecular pathogenesis and therapeutic implications
Abigail N. Layton and Edouard E. Galyov
Abstract
Published 2nd July 2007

Novel therapeutic strategies for the treatment of protein-misfolding diseases
Jean-Christophe Rochet
Abstract
Published 28th June 2007

Chemical and pharmacological chaperones as new therapeutic agents
Tip W. Loo and David M. Clarke
Abstract
Published 28th June 2007

Rearrangements of the Williams–Beuren syndrome locus: molecular basis and implications for speech and language development
Lucy R. Osborne and Carolyn B. Mervis
Abstract
Published 13th June 2007

The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis
Suzie Ariyaratana and David M. Loeb
Abstract
Published 24th May 2007

The heterogeneity of epithelial ovarian cancers: reconciling old and new paradigms
Honami Naora
Abstract
Published 4th May 2007

Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments
Qian Tao and Anthony T.C. Chan
Abstract

Published 4th May 2007

Congenital adrenal hyperplasia: focus on the molecular basis of 21-hydroxylase deficiency
João Gonçalves, Ana Friães and Luís Moura
Abstract
Published 30th April 2007

Immunology of pregnancy: cellular mechanisms allowing fetal survival within the maternal uterus
Ana Claudia Zenclussen, Anne Schumacher, Maria Laura Zenclussen, Paul Wafula and Hans-Dieter Volk
Abstract
Published 27th April 2007

Atopic dermatitis: insights from linkage overlap and disease co-morbidity
Saffron A.G. Willis-Owen, Nilesh Morar and Charles A. Willis-Owen
Abstract
Published 3rd April 2007

The therapeutic potential of gene transfer for the treatment of peripheral neuropathies
James R. Goss
Abstract
Published 19th March 2007

Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention
Stuart P. Atkinson and W. Nicol Keith
Abstract
Published 13th March 2007

Molecular mechanisms of HIV integration and therapeutic intervention
Nick Vandegraaff and Alan Engelman
Abstract
Published 26th February 2007

Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes
Daniel D. Lam and Lora K. Heisler
Abstract
Published 22nd February 2007

Immunological responses can have both pro- and antitumour effects: implications for immunotherapy
Trina J. Stewart, Kristy M. Greeneltch, M.E. Christine Lutsiak and Scott I. Abrams
Abstract
Published 7th February 2007

Age-related changes in immunity: implications for vaccination in the elderly
Rania D. Kovaiou, Dietmar Herndler-Brandstetter and Beatrix Grubeck-Loebenstein
Abstract
Published 1st February 2007

Endometriosis: disease pathophysiology and the role of prostaglandins
Meng-Hsing Wu, Yutaka Shoji, Pei-Chin Chuang and Shaw-Jenq Tsai
Abstract
Published 16th January 2007

The peanut allergy epidemic: allergen molecular characterisation and prospects for specific therapy
Maria P. de Leon, Jennifer M. Rolland and Robyn E. O'Hehir
Abstract
Published 9th January 2007

2006

Post-lactational mammary gland regression: molecular basis and implications for breast cancer
Christine J. Watson
Abstract
Published 20th December 2006

Mechanisms of serpin dysfunction in disease
by Dion Kaiserman, James C. Whisstock and Phillip I. Bird
Abstract
Published 11th December 2006

Tumour–host interactions: implications for developing anti-cancer therapies
by Bedrick B. Gadea and Johanna A. Joyce
Abstract
Published 11th December 2006

Molecular mimicry and horror autotoxicus: do chlamydial infections elicit autoimmunity?
by Robert H. Swanborg, Dov L. Boros, Judith A. Whittum-Hudson and Alan P. Hudson
Abstract
Published 30th November 2006

The interaction of macrophage receptors with bacterial ligands
by Annette Plüddemann, Subhankar Mukhopadhyay and Siamon Gordon
Abstract
Published 22nd November 2006

Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies
by Francis Vasseur, David Meyre and Philippe Froguel
Abstract
Published 20th November 2006

Refractory juvenile idiopathic arthritis: using autologous stem cell transplantation as a treatment strategy
by Nico M. Wulffraat, Ismé M. de Kleer and Berent Prakken
Abstract
Published 15th November 2006

Crystallins and hereditary cataracts: molecular mechanisms and potential for therapy
by Usha P. Andley
Abstract
Published 19th October 2006

Molecular basis of inherited skin-blistering disorders, and therapeutic implications
by Monique Aumailley, Cristina Has, Lucy Tunggal and Leena Bruckner-Tuderman
Abstract
Published 13th October 2006

ErbB receptors and their ligands in the breast
by Cynthia A. Zahnow
Abstract
Published 19th September 2006

GATA factors in vertebrate heart development and disease
by
Alison Brewer and John Pizzey
Abstract
Published 18th September 2006

Interactions between respiratory syncytial virus and the host cell: opportunities for antivirus strategies?
by Richard J. Sugrue
Abstract
Published 7th September 2006

Tryptophan metabolism in the central nervous system: medical implications
by Jon P. Ruddick, Andrew K. Evans, David J. Nutt, Stafford L. Lightman, Graham A.W. Rook and Christopher
A. Lowry
Abstract
Published 31st August 2006

Elastic fibres in health and disease
by Cay M. Kielty
Abstract
Published 8th August 2006

Claudins: emerging targets for cancer therapy
by Scott L. Kominsky
Abstract
Published 4th August 2006

Beckwith–Wiedemann syndrome: multiple molecular mechanisms
by Thorsten Enklaar, Bernhard U. Zabel and Dirk Prawitt
Abstract
Published 17th July 2006

Preclinical applications of imaging for cancer gene therapy
by Arnaud Briat and Georges Vassaux
Abstract
Published 14th July 2006

STAT signalling in the heart and cardioprotection
by
Surinder M. Soond, David S. Latchman and Anastasis Stephanou
Abstract
Published 12th July 2006

Alopecia areata: pathogenesis and potential for therapy
by Wei Lu, Jerry Shapiro, Mei Yu, Armin Barekatain, Blanche Lo, Andreas Finner and Kevin McElwee
Abstract and features
Published 20th June 2006

Molecular biology of Rh proteins and relevance to molecular medicine
by Neil D. Avent, Tracey E. Madgett, Zoe E. Lee, David J. Head, Deborah G. Maddocks and Lucy H. Skinner

Abstract and features
Published 12th June 2006

Implications of reproductive technologies for birth and developmental outcomes: imprinting defects and beyond
by Ariane Paoloni-Giacobino

Abstract and features
Published 5th June
2006


Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment
by Emily F. Goodall and Karen E. Morrison

Abstract and features
Published 24th May 2006

Pathophysiology and therapy for haemoglobinopathies
Part II: thalassaemias
by Fabrizia Urbinati, Catherine Madigan and Punam Malik
Abstract and features
Published 9th May 2006

Pathophysiology and therapy for haemoglobinopathies
Part I: sickle cell disease
by Catherine Madigan and Punam Malik
Abstract and features

The fragile X syndrome: exploring its molecular basis and seeking a treatment
by Barbara Bardoni, Laetitia Davidovic, Mounia Bensaid and Edouard W. Khandjian
Abstract and features

New insights into the functions of anthrax toxin
by David J. Banks, Sabrina C. Ward and Kenneth A. Bradley
Abstract and features

Insights into the immunopathogenesis of malaria using mouse models
by Tracey J. Lamb, Douglas E. Brown, Alexandre J. Potocnik and Jean Langhorne
Abstract and features

DNA-damage response pathways triggered by viral replication
by Alison Sinclair, Sarah Yarranton and Celine Schelcher
Abstract and features

Role for GLUT1 in diabetic glomerulosclerosis
by Charles W. Heilig, Frank C. Brosius III and Carol Cunningham
Abstract and features

Preeclampsia: current understanding of the molecular basis of vascular dysfunction
by Sowndramalingam Sankaralingam, Ivan A. Arenas, Manoj M. Lalu and Sandra T. Davidge
Abstract and features

Molecular pathogenesis of autosomal dominant polycystic kidney disease
by Bradley K. Yoder, Sharon Mulroy, Hannah Eustace, Catherine Boucher and Richard Sandford
Abstract and features

RNA repair for haemophilia A
by Hengjun Chao and Christopher E. Walsh
Abstract and features

2005

T-cell signalling and immune system disorders
by Beverley Wilkinson, Jocelyn S. Downey and Christopher E. Rudd
Abstract and features

Molecular pathogenesis of rheumatic fever and rheumatic heart disease
by Luiza Guilherme, Kellen Faé, Sandra E. Oshiro and Jorge Kalil
Abstract and features

Evolving paradigms in the pathogenesis of HIV-1-associated dementia
by Tracy Fischer-Smith and Jay Rappaport
Abstract and features

Immunopathogenesis of Pneumocystis carinii pneumonia
by Francis Gigliotti and Terry W. Wright
Abstract and features

Current molecular understanding of Axenfeld–Rieger syndrome
by Tord A. Hjalt and Elena V. Semina
Abstract and features

TIMP3 mutation in Sorsby’s fundus dystrophy: molecular insights
by Zheng Li, Michael P. Clarke, Michael D. Barker and Norman McKie
Abstract and features

HLA, CTLA-4 and PTPN22: the shared genetic master-key to autoimmunity?
by Oliver Brand, Stephen Gough and Joanne Heward

Abstract and features

The tumour necrosis factor receptor-associated periodic syndrome: current concepts
by
Silvia Stojanov and Michael F. McDermott
Abstract and features

Relaxin and the extracellular matrix: molecular mechanisms of action and implications for cardiovascular disease
by
Jonathan T. McGuane and Laura J. Parry
Abstract and features

Pathways to improving skin regeneration
by
Christelle Adolphe and Brandon Wainwright
Abstract and features

Human embryonic stem cells: biology and clinical implications
by
Louise A. Hyslop, Lyle Armstrong, Miodrag Stojkovic and Majlinda Lako
Abstract and features

Sperm-based contraceptive vaccines: current status, merits and development
by
Anil Suri
Abstract and features

Molecular medicine of gastric adenocarcinomas
by
Gisela Keller, Heinz Höfler and Karl-Friedrich Becker
Abstract and features

Molecular therapeutic targets in rheumatoid arthritis
by
Sandra M. Sacre, Evangelos Andreakos, Peter Taylor, Marc Feldmann and Brian M. Foxwell
Abstract and features

Molecular and therapeutic aspects of varicella–zoster virus infection
by Mark Quinlivan and Judith Breuer
Abstract and features

Prader–Willi syndrome: clinical genetics, cytogenetics and molecular biology
by Douglas C. Bittel and Merlin G. Butler
Abstract and features

Cellular and molecular mechanisms that underlie Entamoeba histolytica pathogenesis: prospects for intervention
by Richard C. Laughlin and Lesly A. Temesvari
Abstract and features

Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs
by Paul C. Evans
Abstract and features

Nesprins: intracellular scaffolds that maintain cell architecture and coordinate cell function?
by Derek T. Warren, Qiuping Zhang, Peter L. Weissberg and Catherine M. Shanahan
Abstract and features

The phosphoinositide 3-kinase pathway and cancer
by David Stokoe
Abstract and features

The genetic epidemiology of human primary osteoarthritis: current status
by John Loughlin
Abstract and features

Pathogenesis of Wegener’s granulomatosis: current concepts
by Pasha Sarraf and Michael C. Sneller
Abstract and features

Inflammation and atherosclerosis in rheumatoid arthritis
by Robert J. Stevens, Karen M.J. Douglas, Athanasios N. Saratzis and George D. Kitas
Abstract and features

PARP inhibitors for cancer therapy
by Nicola J. Curtin
Abstract and features

Targeting the molecular basis for tumour hypoxia
by Veronica A. Carroll and Margaret Ashcroft
Abstract and features

Chronic tendon pathology: molecular basis and therapeutic implications
by
Graham Riley
Abstract and features

Multiple sclerosis: MHC associations and therapeutic implications
by
Samantha Holmes, Manuel A. Friese, Christian Siebold, E. Yvonne Jones, John Bell and Lars Fugger
Abstract and features

The prospects for vaccines against HIV-1: more than a field of long-term nonprogression?
by Neil Sheppard and Quentin Sattentau
Abstract and features

PPARg as a metabolic regulator: insights from genomics and pharmacology
by
David B. Savage
Abstract and features

2004

Dyskeratosis congenita: molecular insights into telomerase function, ageing and cancer
by
Anna Marrone and Inderjeet Dokal
Abstract and features

Retinoids: potential in cancer prevention and therapy
by
Nicole Clarke, Pierre Germain, Lucia Altucci and Hinrich Gronemeyer
Abstract and features

Chronic idiopathic thrombocytopenic purpura (ITP): molecular mechanisms and implications for therapy
by
Per-Ola Andersson and Hans Wadenvik
Abstract and features

Infectious mononucleosis and Epstein–Barr virus
by
Eleni-Kyriaki Vetsika and Margaret Callan
Abstract and features

SOCS proteins in T helper cell differentiation: implications for allergic disorders?
by
Hiromasa Inoue and Masato Kubo
Abstract and features

Lithium neuroprotection: molecular mechanisms and clinical implications
by
Michael K. Rowe and De-Maw Chuang
Abstract and features

Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions
by Thomas W. Geisbert and Lisa E. Hensley
Abstract and features

Tumour-targeted drug and gene delivery: principles and concepts
by
Jim Cassidy and Andreas G. Schätzlein
Abstract and features

Genetic manipulation of drug sensitivity in haematopoietic cells
by
Thomas Southgate and Leslie J. Fairbairn
Abstract and features

The discovery and role of ADAM33, a new candidate gene for asthma
by
John W. Holloway, Donna E. Davies, Robert Powell, Hans-Michael Haitchi, Tim P. Keith and Stephen T. Holgate
Abstract and features

Parvovirus vectors: use and optimisation in cancer gene therapy
by
Boris Blechacz and Stephen J. Russell
Abstract and features

Diabetes and retinal vascular disorders: role of the renin–angiotensin system
by Jennifer L. Wilkinson-Berka

Abstract and features

Interactions between Neisseria meningitidis and human cells that promote colonisation and disease
by
Anne Corbett, Rachel Exley, Sandrine Bourdoulous and Christoph M. Tang
Abstract and features

Gene therapy for severe combined immune deficiency
by
Waseem Qasim, H. Bobby Gaspar and Adrian J. Thrasher
Abstract and features

Critical evaluation of p53 as a prognostic marker in ovarian cancer
by
Jacqueline Hall, Jim Paul and Robert Brown
Abstract and features

Human pregnancy: the role of chemokine networks at the fetal–maternal interface
by
Kristy Red-Horse, Penelope M. Drake and Susan J. Fisher
Abstract and features

Regulatory SNPs in complex diseases: their identification and functional validation
by
Ludmila Prokunina and Marta E. Alarcón-Riquelme
Abstract and features

Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?
by
Joakim Dillner and Darron R. Brown
Abstract and features

Herpetic eye disease: immunopathogenesis and therapeutic measures
by
Shilpa Deshpande, Kaustuv Banerjee, Partha Sarathi Biswas and Barry T. Rouse
Abstract and features

BAG-1 in carcinogenesis
by
Adam Sharp, Simon J. Crabb, Paul A. Townsend, Ramsey I. Cutress, Matthew Brimmell, Xiu-hong Wang and Graham Packham
Abstract and features

Primary pulmonary hypertension: molecular basis and potential for therapy
by
Nung Rudarakanchana and Nicholas W. Morrell
Abstract and features

Gene therapy for Parkinson’s disease
by
Patricia A. Lawlor and Matthew J. During
Abstract and features

Sepsis: molecular mechanisms underlying lipopolysaccharide recognition
by Martha Triantafilou and Kathy Triantafilou
Abstract and features

SH2 domains: role, structure and implications for molecular medicine
by Gabriel Waksman, Sangaralingam Kumaran and Olga Lubman
Abstract and features

Lyme borreliosis (Lyme disease): molecular and cellular pathobiology and prospects for prevention, diagnosis and treatment
by Paul G. Auwaerter, John Aucott and J. Stephen Dumler
Abstract and features

Molecular aetiology of primary hyperoxaluria and its implications for clinical management
by
Christopher J. Danpure and Gill Rumsby
Abstract and features

2003

Novel concepts in excitotoxic neurodegeneration after stroke
by Michelle M. Aarts, Mark Arundine and Michael Tymianski
Abstract and features

Herpes simplex virus latency
by Robin Lachmann
Abstract and features

Molecular pathogenesis of chronic myeloid leukaemia
by Duncan L. Smith, John Burthem and Anthony D. Whetton

Abstract and features

Hepatocellular carcinoma: molecular interactions between hepatitis C virus and p53 in hepatocarcinogenesis
by Mónica Anzola and Juan José Burgos
Abstract and features

Tissue microarray (TMA) applications: implications for molecular medicine
by Ronald Simon and Guido Sauter
Abstract and features

Molecular mechanisms of learning and memory
by Jane Dunning and Matthew J. During
Abstract and features

Molecular mechanisms by which dietary isoflavones potentially prevent atherosclerosis
by Aedin Cassidy, Sonia de Pascual Teresa and Gerald Rimbach

Abstract and features

Metalloproteinases and their inhibitors in angiogenesis
by Marc A. Lafleur, Madeleine M. Handsley and Dylan R. Edwards

Abstract and features

Nonviral gene delivery: techniques and implications for molecular medicine
by Alan L. Parker, Christopher Newman, Simon Briggs, Leonard Seymour and Paul J. Sheridan
Abstract and features

Repeat expansion and autosomal dominant neurodegenerative disorders: consensus and controversy
by Dobrila D. Rudnicki and Russell L. Margolis
Abstract and features

Huntington’s disease: molecular basis of neurodegeneration
by David C. Rubinsztein and Jenny Carmichael
Abstract and features

Toll-like receptors and intestinal defence: molecular basis and therapeutic implications
by Elke Cario
Abstract and features

A multifaceted role for ATM in genome maintenance
by Tej K. Pandita
Abstract and features

Cobalamin transport proteins and their cell-surface receptors
by Bellur Seetharam and Raghunatha R. Yammani
Abstract and features

Gene therapy for cancer and metastatic disease
by Susan B. Kesmodel and Francis R. Spitz
Abstract and features

Innate immunity and brain inflammation: the key role of complement
by Karen Francis, Johan van Beek, Cecile Canova, Jim W. Neal and Philippe Gasque
Abstract and features

Grb7-based molecular therapeutics in cancer
by Stephanie C. Pero, Roger J. Daly and David N. Krag
Abstract and features

Genetic factors underlying prostate cancer
by Jian-Hua Luo and Yan Ping Yu
Abstract and features

Transgenic mice carrying yeast artificial chromosomes
by Kenneth R. Peterson
Abstract and features

Modern therapeutic approaches in Parkinson’s disease
by Simon J.G. Lewis, Maeve A. Caldwell and Roger A. Barker
Abstract and features

Anti-p53-directed immunotherapy of malignant disease
by Matthias Theobald and Rienk Offringa
Abstract and features

Skin repair and scar formation: the central role of TGF-b
by Steven R. Beanes, Catherine Dang, Chia Soo and Kang Ting
Abstract and features

Cyclooxygenase isoforms and atherosclerosis
by Orina Belton and Desmond J. Fitzgerald
Abstract and features

The genetics of nontuberculous mycobacterial infection
by Melanie Newport
Abstract and features

MHC-based vaccination approaches: progress and perspectives
by Narinder K. Mehra and Gurvinder Kaur
Abstract and features

Molecular basis of hepat