Stephen Man

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Figure 2. Simplified organisation (linearised) of the genome of human papillomavirus type 16 (HPV-16). Simplified organisation of the HPV-16 genome in its linearised state (scale bar is in kilobase pairs). The rectangles represent the positions of various open reading frames (ORFs). The E genes encode proteins that are produced early in the infectious cycle (the non-structural proteins), whereas the L genes encode proteins that are produced late in infection (virion proteins that are necessary for virus assembly). The actual protein products of the genes are complex owing to the production of multiple messenger RNA (mRNA) transcripts (for further details see http://hpv-web.lanl.gov/) (fig002smc).

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